Factors associated with the virological response of lamivudine-resistant hepatitis B virus during combination therapy with adefovir dipivoxil plus lamivudine.

Abstract

BACKGROUND:

The aim of this study was to investigate the factors associated with the response of lamivudine-resistant hepatitis B virus (HBV) during combination therapy with adefovir dipivoxil plus lamivudine.

METHODS:

Sixty-three patients with breakthrough hepatitis received a 10-mg once-daily dose of oral adefovir dipivoxil.

RESULTS:

The rates of undetectable serum HBV-DNA were 49.2% after 24 weeks, 61.9% after 48 weeks, and 67.2% after 72 weeks. The cumulative hepatitis B e antigen (HBeAg) loss rates in patients with alanine aminotransferase (ALT) levels of more than twice the upper limit of normal (ULN) were significantly higher than in patients with ALT less than twice the ULN (P = 0.0145). Multivariate analysis revealed that baseline ALT level (P = 0.003) and HBeAg status (P = 0.049) were associated with early virological response.

CONCLUSIONS:

Baseline ALT level was associated with HBeAg loss and seroconversion, and baseline ALT level and HBeAg status were associated with the virological response of lamivudine-resistant HBV during combination therapy with adefovir dipivoxil plus lamivudine.

• Authors: Tetsuya Hosaka, Fumitaka Suzuki, Yoshiyuki Suzuki, Satoshi Saitoh, Masahiro Kobayashi, Takashi Someya, Hitomi Sezaki, Norio Akuta, Yasuji Arase, Kenji Ikeda, Hiromitsu Kumada
• Journal: Journal of gastroenterology (J Gastroenterol) Vol. 42 Issue 5 Pg. 368-74 (May 2007) ISSN: 0944-1174 [Print] Japan
• PMID: 17530361 (Publication Type: Journal Article)

Chemical References

• Antiviral Agents
• DNA, Viral
• Hepatitis B e Antigens
• Organophosphonates
• Reverse Transcriptase Inhibitors
• Lamivudine
• Alanine Transaminase
• Adenine
• adefovir dipivoxil

Topics

• Adenine (administration & dosage, analogs & derivatives)
• Adult
• Aged
• Alanine Transaminase (blood)
• Antiviral Agents (administration & dosage)
• DNA, Viral (analysis)
• Drug Therapy, Combination
• Female
• Hepatitis
• Hepatitis B e Antigens (analysis)
• Hepatitis B virus (drug effects, genetics)
• Humans
• Lamivudine (administration & dosage, pharmacology)
• Male
• Middle Aged
• Multivariate Analysis
• Organophosphonates (administration & dosage)
• Retrospective Studies
• Reverse Transcriptase Inhibitors (administration & dosage, pharmacology)