Fatal pulmonary arterial occlusive vascular disease following chemotherapy in a 9-month-old infant.

Abstract

Fatal pulmonary hypertension developed in an infant during the 7-month period in which he received, via a central venous catheter, combination chemotherapy for stage IV neuroblastoma as well as intermittent parenteral feeding. In a lung biopsy and at autopsy, small pulmonary arteries showed diffuse medial hypertrophy and peripheral muscularization, very extensive concentric intimal fibrosis, and focal eccentric fibrosis evolving from organizing thrombi. Pulmonary veins were normal. Hypothetically, chemotherapeutic drug therapy (possibly potentiated either by the parenteral nutrition or simply by the vehicular fluids causing volume loading of the pulmonary circulation) could cause occlusive pulmonary arterial disease by several mechanisms, but the association has not been described previously, although use of such drugs has been reported with pulmonary veno-occlusive disease.

• Authors: L Bentur, C Cullinane, P Wilson, M Greenberg, H O'Brodovich, M M Silver
• Journal: Human pathology (Hum Pathol) Vol. 22 Issue 12 Pg. 1295-8 (Dec 1991) ISSN: 0046-8177 [Print] United States
• PMID: 1748437 (Publication Type: Case Reports, Journal Article)

Topics

• Antineoplastic Combined Chemotherapy Protocols (administration & dosage, adverse effects)
• Arterial Occlusive Diseases (chemically induced, etiology, pathology)
• Humans
• Hypertension, Pulmonary (chemically induced, etiology)
• Infant
• Infusions, Intravenous (adverse effects)
• Male
• Parenteral Nutrition (adverse effects)
• Pulmonary Artery (pathology)