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Bacterial N-nitrosation and gastric carcinogenesis in humans.

Abstract
It has been hypothesized that bacterially produced N-nitroso compounds cause the progression from chronic atrophic gastritis through intestinal metaplasia and dysplasia to gastric cancer. If this is true then various consequences follow. These consequences are discussed, together with the evidence for or against them. The conclusion is that there is much to support the hypothesis.
AuthorsM J Hill
JournalThe Italian journal of gastroenterology (Ital J Gastroenterol) Vol. 23 Issue 1 Pg. 17-23 (Jan 1991) ISSN: 0392-0623 [Print] Italy
PMID1747496 (Publication Type: Journal Article, Review)
Chemical References
  • Nitrosamines
  • Nitroso Compounds
Topics
  • Bacterial Physiological Phenomena
  • Humans
  • Hydrogen-Ion Concentration
  • Nitrosamines (metabolism)
  • Nitroso Compounds (metabolism)
  • Stomach (microbiology)
  • Stomach Neoplasms (etiology)

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