Abstract |
Halisulfate 1, a sesterterpene sulfate and an isocitrate lyase (ICL) inhibitor that is isolated from tropical sponge Hippospongia spp., reduces both appressorium formation and infection of rice plants by the fungus Magnaporthe grisea. Rice plants infected with wild-type M. grisea Guy 11 exhibited significantly lower disease severity after halisulfate 1 treatment than without, and the treatment effect was comparable to the behavior of the Delta icl knockout mutant I-10. The protection observed upon applying halisulfate 1 to rice plants suggests that the ICL inhibitor may be a promising candidate for crop protection, particularly to protect rice plants against M. grisea.
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Authors | Dong-Sun Shin, Tae-Hoon Lee, Hyi-Seung Lee, Jongheon Shin, Ki-Bong Oh |
Journal | FEMS microbiology letters
(FEMS Microbiol Lett)
Vol. 272
Issue 1
Pg. 43-7
(Jul 2007)
ISSN: 0378-1097 [Print] England |
PMID | 17456183
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antifungal Agents
- Enzyme Inhibitors
- Fungal Proteins
- Sesterterpenes
- Terpenes
- halisulfate 1
- Isocitrate Lyase
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Topics |
- Antifungal Agents
(pharmacology)
- Enzyme Inhibitors
(pharmacology)
- Fungal Proteins
(antagonists & inhibitors, genetics)
- Gene Deletion
- Isocitrate Lyase
(antagonists & inhibitors, genetics)
- Magnaporthe
(drug effects, genetics, pathogenicity)
- Molecular Structure
- Oryza
(microbiology)
- Plant Diseases
(microbiology)
- Sesterterpenes
- Spores, Fungal
(drug effects)
- Terpenes
(pharmacology)
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