Circulating concentrations of adiponectin and tumor necrosis factor-alpha in gestational diabetes mellitus.

Abstract

Adiponectin and tumor necrosis factor-alpha (TNF-alpha) have been implicated in insulin resistance and diabetes mellitus (DM). In the present study we investigated levels of adiponectin and TNF-alpha and their relationships with each other and metabolic factors in women with gestational DM (GDM). Thirty-four pregnant women with GDM and 31 pregnant women with normal glucose tolerance (NGT) were included in the study. Plasma adiponectin levels were lower in GDM than in NGT (36.9 +/- 6.7 vs. 61.3 +/- 13.0 ng/ml, p = 0.028). Serum TNF-alpha levels were increased in GDM compared with NGT (20.5 +/- 2.4 vs. 14.0 +/- 1.5 pg/ml, p = 0.042). After adjustment for pre-pregnancy and current body mass index (BMI), adiponectin levels correlated negatively with insulin resistance by homeostasis model assessment-insulin resistance (HOMA-IR) and 0-h and 1-h glucose both at glucose challenge test and oral glucose tolerance test in GDM. Adiponectin levels were correlated only with very low-density lipoprotein cholesterol and triglyceride levels in NGT. TNF-alpha levels were correlated with glycated hemoglobin in GDM. There was a significant positive correlation between TNF-alpha levels and pre-pregnancy and current BMI in GDM as well as NGT. HOMA-IR for adiponectin and pre-pregnancy BMI for TNF-alpha remained as significant determinants in multiple regression analyses. In conclusion, these data suggest that reduced adiponectin and increased TNF-alpha may be involved in the pathogenesis of GDM.

• Authors: Alev E Altinova, Fusun Toruner, Nuray Bozkurt, Neslihan Bukan, Ayhan Karakoc, Ilhan Yetkin, Goksun Ayvaz, Nuri Cakir, Metin Arslan
• Journal: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology (Gynecol Endocrinol) Vol. 23 Issue 3 Pg. 161-5 (Mar 2007) ISSN: 0951-3590 [Print] England
• PMID: 17454170 (Publication Type: Journal Article)

Chemical References

• Adiponectin
• Glycated Hemoglobin A
• Hemoglobins
• Tumor Necrosis Factor-alpha
• hemoglobin A1c protein, human

Topics

• Adiponectin (blood)
• Adult
• Body Mass Index
• Diabetes, Gestational (blood, metabolism)
• Female
• Glucose Tolerance Test
• Glycated Hemoglobin
• Hemoglobins (analysis)
• Humans
• Insulin Resistance
• Pregnancy
• Tumor Necrosis Factor-alpha (blood)