Introduction of Haemophilus influenzae type B conjugate vaccine into routine immunization in Ghana and its impact on bacterial meningitis in children younger than five years.

Abstract

This report shows the impact of a pentavalent vaccine that includes Haemophilus influenzae type b (Hib) conjugate vaccine on bacterial meningitis in children younger than 5 years in Ghana. A review of the first 3 years of a pediatric bacterial meningitis surveillance program, started in August 2001 in Accra, Ghana, was undertaken. There was a significant reduction, P = 0.042 and 0.017, in percentage of purulent meningitis in children younger than 1 year, comparing the first year when the vaccine was introduced, to the second and third years, respectively.

• Authors: Lorna Awo Renner, Mercy J Newman, Lawson Ahadzie, Kwadwo Odei Antwi-Agyei, Messeret Eshetu
• Journal: The Pediatric infectious disease journal (Pediatr Infect Dis J) Vol. 26 Issue 4 Pg. 356-8 (Apr 2007) ISSN: 0891-3668 [Print] United States
• PMID: 17414404 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Haemophilus Vaccines
• Vaccines, Conjugate

Topics

• Child, Preschool
• Ghana (epidemiology)
• Haemophilus Vaccines (administration & dosage, immunology)
• Haemophilus influenzae type b (immunology, isolation & purification)
• Humans
• Immunization Programs
• Incidence
• Infant
• Meningitis, Bacterial (epidemiology, microbiology, prevention & control)
• Meningitis, Haemophilus (epidemiology, microbiology, prevention & control)
• Neisseria meningitidis (isolation & purification)
• Streptococcus pneumoniae (isolation & purification)
• Vaccines, Conjugate (administration & dosage, immunology)