[Expression and significance of integrin alpha5, beta1 and E-CD in patients with non-small cell lung carcinoma].

Abstract

OBJECTIVE:

To investigate the relationship between the expressions of integrin alpha5 beta1 and E-CD, and clinicopathological characteristics and prognosis of patients with non-small cell lung carcinoma (NSCLC).

METHODS:

The expression of integrin alpha5 beta1 and E-CD were analyzed in 53 NSCLC and 12 control specimens by immunohistochemical assay.

RESULTS:

The expression of integrin alpha5 beta1 was significantly higher in NSCLC (58.5%) than that in normal lung tissue (16.7%), and also positively related with pathological characteristics (P = 0.021), lymph node metastasis (P = 0.006), and clinical stage (P = 0.002). The 3-year survival rate in NSCLC group was significantly lower than that in control group (22.3% vs 40.6% , P = 0.041). The positive expression of E-CD in NSCLC and control group was 32.1% and 91.7%, respectively, and negatively correlated with pathological characteristics (P = 0.010) and lymph node metastasis (P = 0.002). The 3-year survival rate in control group was 19.9%, lower than that in NSCLC group (41.2%, P > 0.05), but the difference is not significant.

CONCLUSION:

The overexpression of integrin alpha5 beta1 may contribute to lymph node metastasis and play an inverse role, while E-CD may be a beneficial prognostic factor in patients with NSCLC.

• Authors: Qi-Sen Guo, Hui Jia, Ming-Yong Han, Jin-Ming Yu, Wei-Xia Zhong
• Journal: Zhonghua zhong liu za zhi [Chinese journal of oncology] (Zhonghua Zhong Liu Za Zhi) Vol. 28 Issue 10 Pg. 746-9 (Oct 2006) ISSN: 0253-3766 [Print] China
• PMID: 17366785 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Cadherins
• Integrin alpha5beta1

Topics

• Adult
• Aged
• Cadherins (metabolism)
• Carcinoma, Non-Small-Cell Lung (metabolism, pathology)
• Female
• Humans
• Immunohistochemistry
• Integrin alpha5beta1 (metabolism)
• Lung Neoplasms (metabolism, pathology)
• Lymphatic Metastasis
• Male
• Middle Aged
• Neoplasm Staging
• Smoking
• Survival Analysis