Abstract | BACKGROUND: It is believed widely that chemotherapy-induced cognitive impairment occurs in a subgroup of patients with breast cancer. However, recent reports have provided no evidence that chemotherapy affects cognition. In this study, the authors questioned whether cognitive compromise in patients with breast cancer is attributable to chemotherapy. In addition, the effects of therapy-induced menopause and of the erythropoiesis-stimulating factor darbepoetin alpha on cognitive performance were assessed. METHODS: RESULTS: At T1, the group means ranged below the test norms in 5 of 12 cognitive tests. At T2, multiple analyses of variance (MANOVA) indicated a significant overall improvement in the test results (P<.001). After correcting for practice effects, cognitive decline predominated in 27% of patients, whereas improvement predominated in 28% of patients. Cognitive performance was not related significantly to self-reported cognitive problems, anxiety and depression, menopause, or darbepoetin alpha administration. CONCLUSIONS: Even before chemotherapy, a subgroup of patients with breast cancer showed cognitive compromise that was unrelated to anxiety or depression. During chemotherapy, cognitive function remained stable in most patients, improved in a subgroup, and deteriorated in another subgroup. The deterioration may have been caused by side effects of chemotherapy, but it also may have been related to currently unidentified factors that cause prechemotherapy cognitive compromise. Therapy-induced menopause and darbepoetin alpha did not appear to influence cognition.
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Authors | Kerstin Hermelink, Michael Untch, Michael P Lux, Rolf Kreienberg, Thomas Beck, Ingo Bauerfeind, Karin Münzel |
Journal | Cancer
(Cancer)
Vol. 109
Issue 9
Pg. 1905-13
(May 01 2007)
ISSN: 0008-543X [Print] United States |
PMID | 17351951
(Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | Copyright (c) 2007 American Cancer Society |
Chemical References |
- Hematinics
- Erythropoietin
- Darbepoetin alfa
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Topics |
- Adult
- Aged
- Antineoplastic Combined Chemotherapy Protocols
(adverse effects)
- Breast Neoplasms
(drug therapy)
- Cognition
(drug effects)
- Cognition Disorders
(chemically induced)
- Darbepoetin alfa
- Erythropoietin
(analogs & derivatives, therapeutic use)
- Female
- Hematinics
(therapeutic use)
- Humans
- Longitudinal Studies
- Menopause
(drug effects)
- Middle Aged
- Neoadjuvant Therapy
(adverse effects)
- Neuropsychological Tests
- Prospective Studies
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