HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Incidence, risk factors, and predictors of outcome of candidemia. Survey in 2 Italian university hospitals.

Abstract
In recent decades, Candida spp. emerged as the fourth most common cause of nosocomial bloodstream infections. The incidence of candidemia was 0.13 per 100 persons. Eighty-three cases (61%) of candidemia were due to Candida albicans and 53 (39%) to nonalbicans Candida spp. Twelve strains of Candida (9%) had shown in vitro resistance to fluconazole, 5 (4%) to itraconazole, 2 (1.5%) to voriconazole, 12 (9%) to 5-flucytosine, and 1 (0.7%) to amphotericin B. Multivariate logistic regression analysis of risk factors showed that length of hospitalization, presence of a central venous catheter, previous episodes of candidemia or bacteremia, parenteral nutrition, and chronic renal failure were variables independently associated with the development of candidemia. Multivariate logistic regression analysis of prognostic indicators showed that the independent variables associated with poor prognosis were inadequate initial therapy (P < .001) and high APACHE III score (P = .004). The inadequate initial therapy associated with mortality indicates the need for additional investigations to define high-risk patients for beneficial antifungal prophylaxis.
AuthorsMatteo Bassetti, Enrico Maria Trecarichi, Elda Righi, Maurizio Sanguinetti, Francesca Bisio, Brunella Posteraro, Ornella Soro, Roberto Cauda, Claudio Viscoli, Mario Tumbarello
JournalDiagnostic microbiology and infectious disease (Diagn Microbiol Infect Dis) Vol. 58 Issue 3 Pg. 325-31 (Jul 2007) ISSN: 0732-8893 [Print] United States
PMID17350205 (Publication Type: Journal Article)
Chemical References
  • Antifungal Agents
Topics
  • Aged
  • Antifungal Agents (pharmacology)
  • Candidiasis (epidemiology)
  • Catheterization, Central Venous
  • Cross Infection (epidemiology, microbiology)
  • Drug Resistance, Fungal
  • Female
  • Fungemia (epidemiology)
  • Hospitals, University
  • Humans
  • Incidence
  • Italy (epidemiology)
  • Kidney Failure, Chronic (complications)
  • Length of Stay
  • Male
  • Microbial Sensitivity Tests
  • Middle Aged
  • Multivariate Analysis
  • Parenteral Nutrition
  • Risk Factors
  • Treatment Outcome

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: