Association of serum levels of IGF-I and IGFBP-1 with renal function in patients with type 2 diabetes mellitus.

Abstract

OBJECTIVE:

Our aim was to determine whether serum Insulin-like growth factor-I (IGF-I) and Insulin-like growth factor binding protein-1 (IGFBP-1) levels were different between type 2 diabetic patients and non-diabetic control group. We also aimed to establish any relationship that might exist between the serum IGF-I and IGFBP-1 levels with the urinary albumin excretion (UAE), creatinine clearance and urinary N-acetyl-beta-D-glucosaminidase (NAG) excretion (as a marker of renal tubular dysfunction) and other parameters (such as age, duration of diabetes, treatment, etc.) in patients with type 2 diabetes mellitus (DM).

DESIGN:

Fifty-nine type 2 diabetic patients and thirty-one non-diabetic controls were included in this study.

RESULTS:

Mean serum IGF-I levels in diabetic patients were lower than the non-diabetic controls (158+/-12 vs. 287+/-26microg/l), (p<0.001). Serum IGFBP-1 levels were also higher in type 2 diabetic patients compared to the control group (67+/-5 vs. 35+/-4microg/l), (p<0.001). No relationship was obtained between IGF-I and IGFBP-1 levels with neither UAE nor urinary NAG excretion. A significant negative relationship was observed between creatinine clearance and serum IGFBP-1 level (r=-0.39, p=0.004). In multiple regression analysis IGF-I was independently and negatively associated with age and insulin treatment. On the other hand, IGFBP-1 was negatively related with creatinine clearance and positively related with the duration of diabetes.

CONCLUSION:

These results suggest that type 2 DM leads to a decrease in the IGF-I while elevating the IGFBP-1 levels. Further studies are needed to clarify a potential role of increased levels of IGFBP-1 in decreased creatinine clearance in type 2 DM.

• Authors: Mujde Akturk, Metin Arslan, Alev Altinova, Aysegul Ozdemir, Reyhan Ersoy, Ilhan Yetkin, Elif Ayvali, Sevim Gonen, Fusun Toruner
• Journal: Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society (Growth Horm IGF Res) Vol. 17 Issue 3 Pg. 186-93 (Jun 2007) ISSN: 1096-6374 [Print] Scotland
• PMID: 17329141 (Publication Type: Journal Article)

Chemical References

• Insulin-Like Growth Factor Binding Protein 1
• Insulin-Like Growth Factor I
• Creatinine
• Acetylglucosaminidase

Topics

• Acetylglucosaminidase (urine)
• Creatinine (urine)
• Diabetes Mellitus, Type 2 (blood)
• Female
• Humans
• Insulin-Like Growth Factor Binding Protein 1 (blood)
• Insulin-Like Growth Factor I (analysis)
• Kidney (physiopathology)
• Male
• Middle Aged