[Pure red cell aplasia successfully treated with rituximab in a patient with relapsed diffuse large B-cell lymphoma].

Abstract

Malignant lymphoma is often accompanied by an autoimmune disorder. Here, we describe a 82-year-old woman with pure red cell aplasia (PRCA) complicated with relapsed diffuse large B-cell lymphoma. Primary treatment involving chemotherapy, continuous oral administration of prednisolone and a single infusion of rituximab was unsuccessful for both diseases, but the following treatments with 3 courses of rituximab alone for once a week dramatically improved the PRCA as well as the lymphoma. As PRCA complicated with lymphoma is rare, the ideal therapeutic strategy has not yet been established for it. Rituximab may be a good alternative for treating such cases.

• Authors: Takayuki Suzuki, Takashi Kumagai, Asako Kitano, Humito Kubo, Mikio Tabata, Yuji Kimura, Osamu Miura, Yasufumi Imai
• Journal: [Rinsho ketsueki] The Japanese journal of clinical hematology (Rinsho Ketsueki) Vol. 48 Issue 1 Pg. 67-70 (Jan 2007) ISSN: 0485-1439 [Print] Japan
• PMID: 17313080 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Antibodies, Monoclonal
• Antibodies, Monoclonal, Murine-Derived
• Antineoplastic Agents
• Rituximab

Topics

• Aged, 80 and over
• Antibodies, Monoclonal (therapeutic use)
• Antibodies, Monoclonal, Murine-Derived
• Antineoplastic Agents (therapeutic use)
• Female
• Humans
• Lymphoma, B-Cell (complications)
• Lymphoma, Large B-Cell, Diffuse (complications)
• Red-Cell Aplasia, Pure (complications, drug therapy)
• Rituximab