The SAG1 Toxoplasma gondii surface protein is not required for acute ocular toxoplasmosis in mice.

Abstract	The SAG1 Toxoplasma gondii surface protein stimulates acute ileitis. To determine whether SAG1 is also important in the eye, wild-type or SAG1 knockout parasites were injected intravitreally into mice. No differences in retinal damage or parasite growth were observed, indicating that unlike the case for the intestine, factors besides SAG1 are important for retinal damage.
Authors	Elizabeth Charles, Michelle C Callegan, Ira J Blader
Journal	Infection and immunity (Infect Immun) Vol. 75 Issue 4 Pg. 2079-83 (Apr 2007) ISSN: 0019-9567 [Print] United States
PMID	17283084 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Antigens, Protozoan Protozoan Proteins SAG1 antigen, Toxoplasma Virulence Factors
Topics	Animals Antigens, Protozoan (genetics, physiology) Disease Models, Animal Eye (parasitology) Gene Deletion Histocytochemistry Mice Mice, Inbred C57BL Microscopy Protozoan Proteins (genetics, physiology) Retina (pathology) Toxoplasma (pathogenicity) Toxoplasmosis, Ocular (microbiology) Virulence Factors (genetics, physiology)

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