Abstract | OBJECTIVES: PATIENTS AND METHODS: Serum samples were collected on admission from 25 children with ALF (median age, 11.1 y; range, 1.3-17.1 y; 11 male, 14 female) and 12 normal children (9.1 y; range, 5.4-15.4 y; 6 male, 6 female). Aetiology of ALF was 13 non-A to E hepatitis, 3 viral, 3 toxic, and 6 other. HGF and VEGF in sera were assayed by enzyme-linked immunosorbent assay. RESULTS: Median HGF levels in patients (10,157 pg/mL; range, 3412-73,420 pg/mL) were significantly higher than in controls (855 pg/mL, 510-1253 pg/mL; P < 0.001). Median VEGF levels in patients (164 pg/mL, 0-1588 pg/mL) were not significantly different from those in controls (214 pg/mL, 11-527 pg/mL). There was no relationship of HGF or VEGF levels to the aetiology of liver failure. There was a positive correlation between serum HGF and international normalized ratio (r = 0.73, P < 0.001), but not with levels of serum aspartate aminotransferase, bilirubin, or VEGF. There was no correlation between VEGF levels and international normalized ratio, aspartate aminotransferase or bilirubin. CONCLUSIONS:
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Authors | Marion M Aw, Ragai R Mitry, Robin D Hughes, Anil Dhawan |
Journal | Journal of pediatric gastroenterology and nutrition
(J Pediatr Gastroenterol Nutr)
Vol. 44
Issue 2
Pg. 224-7
(Feb 2007)
ISSN: 1536-4801 [Electronic] United States |
PMID | 17255836
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Vascular Endothelial Growth Factor A
- Hepatocyte Growth Factor
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Topics |
- Adolescent
- Child
- Child, Preschool
- Female
- Hepatocyte Growth Factor
(blood)
- Humans
- Infant
- Liver Failure, Acute
(blood)
- Male
- Prognosis
- Vascular Endothelial Growth Factor A
(blood)
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