Cerebral salt wasting in a patient with head trauma: management with saline hydration and fludrocortisone.

Abstract

Hyponatremia secondary to the syndrome of inappropriate anti-diuretic hormone secretion is commonly observed in patients with various neurological disorders. Cerebral salt wasting (CSW), although uncommon, has also been reported to frequently result in hyponatremia. Here, we report a case of CSW in a patient with head trauma without evidence of cerebrovascular injury or brain edema. He was diagnosed on the basis of high fractional excretion of urinary sodium and uric acid along with extremely low serum uric acid. Improvements in serum sodium levels after saline hydration and fludrocortisone administration further supported the diagnosis, even in the presence of normal brain and atrial natriuretic peptide levels.

• Authors: Akram Askar, Nauman Tarif
• Journal: Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia (Saudi J Kidney Dis Transpl) Vol. 18 Issue 1 Pg. 95-9 (Mar 2007) ISSN: 1319-2442 [Print] Saudi Arabia
• PMID: 17237900 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anti-Inflammatory Agents
• Sodium Chloride
• Fludrocortisone

Topics

• Adolescent
• Anti-Inflammatory Agents (therapeutic use)
• Craniocerebral Trauma (complications, therapy)
• Fludrocortisone (therapeutic use)
• Fluid Therapy
• Humans
• Hyponatremia (diagnosis, etiology, therapy)
• Male
• Skull Fractures (complications, etiology, therapy)
• Sodium Chloride (therapeutic use)
• Treatment Outcome