Abstract |
We aim to investigate the anticancer effect of a novel immunomodulator FTY720 on a rat orthotopic liver tumor model. A buffalo rat orthotopic liver tumor model was established by injection of a buffalo hepatoma cell line MH7777 into the right portal vein. FTY720 was administered by intraperitoneal injection starting at 10 days after tumor cell injection at a dosage of 5 mg/kg/day. FTY720 markedly suppressed tumor growth and inhibited tumor progression by selective induction of apoptosis of tumor cells via down-regulation of phospho-Akt(ser473) and up-regulation of cleaved caspase-3, together with decrease of focal adhesion kinase. Moreover, the proliferation index of tumor cells was significantly reduced to 15.92+/-5.03% by FTY720 compared with that of 42.92+/-4.47% in the control group (p<0.001). In addition, we confirmed that FTY720 caused no effect on infiltrated lymphocyte in tumor tissue. We conclude that FTY720 is an effective anticancer agent for liver tumor in a rat model without affecting the immune system of the host.
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Authors | Kevin T Ng, Kwan Man, Joanna W Ho, Chris K Sun, Terence K Lee, Yi Zhao, Chung Mau Lo, Ronnie T Poon, Sheung Tat Fan |
Journal | International journal of oncology
(Int J Oncol)
Vol. 30
Issue 2
Pg. 375-80
(Feb 2007)
ISSN: 1019-6439 [Print] Greece |
PMID | 17203219
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antineoplastic Agents
- Immunosuppressive Agents
- Propylene Glycols
- Proto-Oncogene Proteins c-akt
- Fingolimod Hydrochloride
- Sphingosine
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Topics |
- Animals
- Antineoplastic Agents
(pharmacology)
- Cell Line, Tumor
- Cell Proliferation
- Cell Survival
- Disease Progression
- Down-Regulation
- Fingolimod Hydrochloride
- Gene Expression Regulation, Neoplastic
- Immunosuppressive Agents
(pharmacology)
- Liver Neoplasms
(drug therapy, immunology, metabolism)
- Lymphocytes
(metabolism)
- Neoplasm Transplantation
- Propylene Glycols
(pharmacology)
- Proto-Oncogene Proteins c-akt
(physiology)
- Rats
- Sphingosine
(analogs & derivatives, pharmacology)
- Up-Regulation
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