[Histochemical investigations on liver and kidney of the rat after intoxication with organophosphates (author's transl)].

Abstract

Comparative histochemical investigations of the livers and kidneys of female Sprague-Dawley rats were made: 1. after intoxication with O-pinacolyl-methyl-phosphonylfluoride (Soman), O,O-diethyl-O-p-nitrophenylphosphate (Paraoxon, E 600); 2. after starvation of 24 to 36 h; 3. after hypoxia for 24 h. From the results it is concluded that the fatty degeneration of liver and kidney after PE.-intoxication is caused by intracellular hypoxia. No fatty degeneration of the organs was observed following deprivation of food for 36 h. A decreased level of cholin which might be caused by the intoxication with PE., and which could be the reason for the fatty degeneration was not found. This was indicated by the unaltered evidence of phosphatids in the intoxicated animals.

• Authors: H Hettwer
• Journal: Acta histochemica (Acta Histochem) Vol. 52 Issue 2 Pg. 239-52 ( 1975) ISSN: 0065-1281 [Print] Germany
• Vernacular Title: Histochemische Untersuchungen an Leber und Niere der Ratte nach Phosphorsäureestervergiftung
• PMID: 171902 (Publication Type: Journal Article)

Chemical References

• Organophosphorus Compounds
• Pyruvate Dehydrogenase Complex
• Soman
• Hydroxybutyrate Dehydrogenase
• Malate Dehydrogenase
• Isocitrate Dehydrogenase
• Glucosephosphate Dehydrogenase
• Ketoglutarate Dehydrogenase Complex
• Succinate Dehydrogenase
• Cytochrome Reductases
• Electron Transport Complex IV
• Esterases
• Lipase
• Alkaline Phosphatase
• Acid Phosphatase
• Glucose-6-Phosphatase
• Glucuronidase
• Paraoxon

Topics

• Acid Phosphatase (metabolism)
• Alkaline Phosphatase (metabolism)
• Animals
• Cytochrome Reductases (metabolism)
• Electron Transport Complex IV (metabolism)
• Esterases (metabolism)
• Fatty Liver (chemically induced)
• Female
• Glucose-6-Phosphatase (metabolism)
• Glucosephosphate Dehydrogenase (metabolism)
• Glucuronidase (metabolism)
• Hydroxybutyrate Dehydrogenase (metabolism)
• Hypoxia (physiopathology)
• Isocitrate Dehydrogenase (metabolism)
• Ketoglutarate Dehydrogenase Complex (metabolism)
• Kidney (metabolism)
• Lipase (metabolism)
• Lipid Metabolism
• Liver (metabolism)
• Malate Dehydrogenase (metabolism)
• Organophosphorus Compounds (toxicity)
• Paraoxon (toxicity)
• Pyruvate Dehydrogenase Complex (metabolism)
• Rats
• Soman (toxicity)
• Starvation (physiopathology)
• Succinate Dehydrogenase (metabolism)