Dengue hemorrhagic Fever caused by sequential dengue 1-3 virus infections over a long time interval: Havana epidemic, 2001-2002.

Abstract

A dengue epidemic caused by dengue virus 3 (DENV-3) occurred in Cuba in 2001-2002. It included cases of dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS). We report neutralizing antibody studies on sera from 54 of 78 DHF/DSS patients that provide evidence of infections occurring in the sequence DENV-1 followed by DENV-3. No sera showed infection in the sequence DENV-2 followed by DENV-3. Some sera showed a pattern of infection in the sequence DENV-1 followed by DENV-2 and then DENV-3. However definitive categorization of a tertiary infection was not possible because of broadly reactive antibodies, which could have been raised by infections in the sequence DENV-1 then DENV-3.

• Authors: Mayling Alvarez, Rosmari Rodriguez-Roche, Lídice Bernardo, Susana Vázquez, Luis Morier, Daniel Gonzalez, Osvaldo Castro, Gustavo Kouri, Scott B Halstead, Maria G Guzman
• Journal: The American journal of tropical medicine and hygiene (Am J Trop Med Hyg) Vol. 75 Issue 6 Pg. 1113-7 (Dec 2006) ISSN: 0002-9637 [Print] United States
• PMID: 17172378 (Publication Type: Journal Article)

Chemical References

• Antibodies, Viral

Topics

• Antibodies, Viral (blood)
• Cuba (epidemiology)
• Dengue Virus (classification, isolation & purification)
• Humans
• Neutralization Tests
• Severe Dengue (epidemiology)
• Time Factors