Survival analysis in patients with upper urinary tract transitional cell carcinoma: a comparison between open and hand-assisted laparoscopic nephroureterectomy.

Abstract

OBJECTIVE:

To evaluate the stage- and grade-specific survival rate in patients with upper urinary tract (UUT) transitional cell carcinoma (TCC) after open (ONU) or hand-assisted laparoscopic nephroureterectomy (LNU) with bladder-cuff excision.

PATIENTS AND METHODS:

From January 1998 to April 2005, 143 patients with UUT-TCC were treated with either ONU or LNU and enrolled in the study. The peri-operative data were collected by retrospective chart review. The recurrence, metastasis and survival rate were calculated.

RESULTS:

The 5-year disease-specific survival of patients with pT1 disease was 88.1% after ONU and 92.0% after LNU (P = 0.745); the respective values for patients with pT2 were 11/17 and 12/15 (P = 0.874), and for pT3 were six/11 and 12/15 (P = 0.476). The incidence of bladder recurrence within 2 years after surgery was 24.7% for ONU and 19.7% for LNU (P = 0.475).

CONCLUSION:

The results were similar after ONU or LNU with bladder-cuff excision; bladder-cuff excision using a hand-assisted device is effective and serves as a treatment option for patients with UUT-TCC.

• Authors: Thomas Y Hsueh, Yi-Hsiu Huang, Allen W Chiu, Steven K Huan, Ying-Huei Lee
• Journal: BJU international (BJU Int) Vol. 99 Issue 3 Pg. 632-6 (Mar 2007) ISSN: 1464-4096 [Print] England
• PMID: 17166239 (Publication Type: Comparative Study, Evaluation Study, Journal Article)

Topics

• Aged
• Carcinoma, Transitional Cell (mortality, surgery)
• Disease-Free Survival
• Female
• Humans
• Laparoscopy (mortality, standards)
• Male
• Neoplasm Metastasis
• Neoplasm Recurrence, Local
• Neoplasm Staging
• Nephrectomy (methods, mortality, standards)
• Retrospective Studies
• Survival Analysis
• Treatment Outcome
• Ureter (surgery)
• Urologic Neoplasms (mortality, surgery)