[Association of fibrinogen B beta -1420G/A, -993C/T and -854G/A gene polymorphism with coronary heart disease].

Abstract

OBJECTIVE:

To analyze the frequency of FGB gene -1420G/A, -993C/T and -854G/A polymorphisms, and their association with plasma fibrinogen levels in patients with coronary heart disease and in health adults.

METHODS:

The FGB gene -1420G/A, -993C/T and -854G/A polymorphisms were analyzed with restriction fragment length polymorphisms, polymerase chain reaction with allele-specific primer and nucleotide sequencing methods. Plasma fibrinogen levels were determined by turbidimetry.

RESULTS:

The frequencies of -1420A were 0.33 in patients with coronary heart disease and 0.26 in health adults. The frequencies of -1420A in coronary heart disease were apparently higher than that in health adults. There were no difference in frequencies of other two alleles. The logistic study suggested -1420G/A polymorphism was associated with coronary heart disease. There are significantly difference in plasma fibrinogen levels in two groups. Plasma fibrinogen levels were significantly increased in patients with coronary heart disease.

CONCLUSION:

This study suggests -1420G/A polymorphism may be associated with occurrence of coronary heart disease.

• Authors: Hong-yun Xing, Wang-wei Cai, Xiao-ming Li, Qiao Fu, Guo-xun Liu
• Journal: Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics (Zhonghua Yi Xue Yi Chuan Xue Za Zhi) Vol. 23 Issue 6 Pg. 622-6 (Dec 2006) ISSN: 1003-9406 [Print] China
• PMID: 17160939 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• BBeta fibrinogen
• Fibrinogen
• DNA

Topics

• Adult
• Aged
• Aged, 80 and over
• Alleles
• Base Sequence
• Coronary Disease (genetics, metabolism)
• DNA (chemistry, genetics)
• Female
• Fibrinogen (genetics, metabolism)
• Gene Frequency
• Genotype
• Haplotypes
• Humans
• Male
• Middle Aged
• Molecular Sequence Data
• Polymerase Chain Reaction
• Polymorphism, Restriction Fragment Length
• Polymorphism, Single Nucleotide
• Sequence Analysis, DNA