parvaquone (993C)

04/01/1989 - "Schizont-infected cell lines derived by in vitro infection of bovine T cell clones with the Muguga isolate of Theileria parva were treated for 72 hr with the theileriacidal drug, parvaquone, at a concentration of 10 micrograms/ml. This treatment completely eliminated schizonts from the recovered cells, which failed to undergo further proliferation and died. "
01/01/1988 - "Groups of seven cattle were infected with Theileria parva stabilate and treated with parvaquone (20 mg kg-1 bodyweight) zero, four, eight, 12, 14 or 16 days after infection. "
11/01/1987 - "When given at 3 different dosages and treatment schedules, parvaquone was ineffective in clearing carrier infection. "
07/01/1985 - "One group received 20 mg (kg bodyweight)-1 of parvaquone 10 days after infection. "
07/01/1985 - "Treatment of Theileria annulata infection in calves with parvaquone."

08/01/1988 - "Efficacy of parvaquone in the treatment of naturally occurring theileriosis in cattle in Iraq."
02/01/1987 - "Field evaluation of parvaquone against naturally occurring East Coast fever."
05/24/1986 - "Clinical trial of parvaquone for the treatment of East Coast fever in Kenya."
09/28/1985 - "Parvaquone was used to treat 126 cattle with theileriosis. "
09/28/1985 - "Treatment of theileriosis with parvaquone in Zambia."

02/01/1990 - "Domestic cats were inoculated subcutaneously with blood from a cat infected with Cytauxzoon felis and treated daily with either 20 or 30 mg kg-1 parvaquone, or 5 or 10 mg kg-1 buparvaquone, beginning on either the first day parasites were detected in peripheral blood, or 2 days after the onset of parasitemia. "
11/01/1987 - "Parvaquone given IM once at a dosage of 20 mg/kg was effective for acute B equi infections in splenectomized ponies; parasitemia began to decrease within 24 hours after treatment. "
12/01/1987 - "A cat which had recovered from Cytauxzoon felis infection following treatment with the anti-theilerial drug, parvaquone, showed an increase in piroplasm parasitemia after splenectomy and its blood was suitable for the preparation of antigen smears for the indirect fluorescent antibody test. "

08/01/1986 - "Two separate doses of parvaquone of 10 mg kg-1 administered on the first and second days of fever protected four out of five calves. "
09/01/1984 - "One of five animals treated with parvaquone and three of six treated with halofuginone on the sixth day of fever died of theileriosis."
09/01/1984 - "All animals treated with parvaquone or halofuginone lactate on the first or third day of fever underwent relatively mild theileriosis and all of them recovered. "
09/01/1984 - "Seven groups of calves were treated with parvaquone (993C: Clexon, Wellcome) (20 mg kg-1 intramuscularly) or halofuginone lactate (1.2 mg kg-1 orally) on the first, third or sixth day of significant pyrexia following artificial infection with the Hissar strain of Theileria annulata. "

11/01/1985 - "Boran (Bos indicus) heifers were immunised by infection with local Theileria parva parva, T p lawrencei and T mutans stocks and treated with parvaquone and later exposed to natural tick and tick-borne disease challenge in the Trans-Mara Division of Kenya. "