[Chemopreventive effect of celecoxib against DMBA-induced breast cancer and its mechanism].

Abstract

OBJECTIVE:

To evaluate the chemopreventive effect of celecoxib, a specific cyclooxegenease-2 (COX-2) inhibitor, on chemically induced breast cancer of rats and its effect on COX-2 expression.

METHODS:

7, 12-dimethylbenz anthracene (DMBA) was administered intragastrically in SD female rats to establish breast cancer models, which were divided subsequently into control group, tamoxifen group and celecoxib group to receive different treatments accordingly. The occurrence rate of breast cancer was observed and the effect of celecoxib on COX-2 and vascular endothelial growth factor (VEGF) expressions assayed by immunohistochemical SP method.

RESULTS:

The incidence of breast cancer in tamoxifen group (48.15%) and celecoxib group (50.00%) were both significantly lower than that in the control group (85.71%; P=0.003 and P=0.004, respectively). The positivity rate of COX-2 expression in celecoxib group (28.57%) was significantly lower than those of tamoxifen group (48.15%) and control group (83.33%; P=0.001 and P=0.035, respectively). The positivity rate of VEGF expression in celecoxib group (42.86%) was significantly lower than that of control group (79.17%, P=0.023), but comparable with that in tamoxifen group (46.15%, P=0.863).

CONCLUSION:

Celecoxib can significantly suppress DMBA-induced breast cancer in female rats possibly through down-regulation of COX-2 and VEGF expressions.

• Authors: Hua-feng Kang, Xi-jing Wang, Xiao-xu Liu, Zhi-jun Dai, Feng-jie Xue, Xing-huan Xue
• Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University (Nan Fang Yi Ke Da Xue Xue Bao) Vol. 26 Issue 11 Pg. 1599-602 (Nov 2006) ISSN: 1673-4254 [Print] China
• PMID: 17121709 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Cyclooxygenase Inhibitors
• Pyrazoles
• Sulfonamides
• Vascular Endothelial Growth Factor A
• Tamoxifen
• 9,10-Dimethyl-1,2-benzanthracene
• Cyclooxygenase 2
• Celecoxib

Topics

• 9,10-Dimethyl-1,2-benzanthracene
• Animals
• Celecoxib
• Cyclooxygenase 2 (metabolism)
• Cyclooxygenase Inhibitors (therapeutic use)
• Down-Regulation (drug effects)
• Female
• Immunohistochemistry
• Mammary Neoplasms, Experimental (chemically induced, metabolism, prevention & control)
• Pyrazoles (therapeutic use)
• Rats
• Rats, Sprague-Dawley
• Sulfonamides (therapeutic use)
• Tamoxifen (therapeutic use)
• Treatment Outcome
• Vascular Endothelial Growth Factor A (metabolism)