Abstract |
Endocrine disturbances are emerging as major side effects of antipsychotic medications. Of particular note is the profile of menstrual disturbance and galactorrhea as a consequence of hyperprolactinemia (A. Weick & P. M. Haddad, 2003), a sequela of antidopaminergic action at the hypothalamopituitary axis. Research into the clinical aspects of this sensitive issue is sparse. The authors completed a cross-sectional descriptive study of 50 patients on conventional antipsychotic medications. The prevalence of menstrual disturbance was 54%, and the prevalence of amenorrhea was 12%. Symptoms of galactorrhea were present in 32% of patients. A history of pregnancy and childbirth was noted to be significantly associated with the development of galactorrhea (p = .01). The authors hypothesized that pregnancy and lactation might sensitize the hypothalamopituitary axis for further development of hyperprolactinemia due to medications.
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Authors | Karthik Thangavelu, S Geetanjali |
Journal | Experimental and clinical psychopharmacology
(Exp Clin Psychopharmacol)
Vol. 14
Issue 4
Pg. 459-60
(Nov 2006)
ISSN: 1064-1297 [Print] United States |
PMID | 17115873
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Amenorrhea
(chemically induced)
- Antipsychotic Agents
(adverse effects)
- Cross-Sectional Studies
- Female
- Galactorrhea
(chemically induced)
- Humans
- Menstrual Cycle
(drug effects)
- Middle Aged
- Pregnancy
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