Abstract | INTRODUCTION: PATIENTS AND METHODS: Between April 1986 and July 2004, we performed 1000 OLT in a population of 888 recipients. This study was performed in a sample of 701 adult recipients who survived >2 months after transplantation: 276 patients (39.4%) underwent OLT for alcoholic cirrhosis (AC-group), and 425 (60.6%) for nonalcoholic disease (N-AC). The overall incidence of de novo skin tumors was 3.5% (25 tumors): 5.4% (15 tumors) in the AC-group and 2.4% (10 tumors) in the N-AC group (P = .027). Two patients developed two tumors. There were 19 men and 4 women, mean age at OLT of 54.4 +/- 6.8 years (range, 40 to 66 years). The mean time from OLT to tumor diagnosis was 66.1 +/- 51.4 months (range, 3 to 165 months): 56.4 +/- 44.4 months in the AC-group versus 80.6 +/- 59.8 months in the N-AC group (P = NS). Histologically, 17 tumors (68%) were basal cell carcinomas and eight tumors (32%) were squamous cell carcinomas (P = .128). Fourteen patients (60.8%) were smokers: 11 patients (84.6%) in the AC-group versus 3 patients (30%) in the N-AC group (P = .012). All the patients underwent tumor resection, with only one patient dying, because of lymph node invasion of the neck. CONCLUSION:
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Authors | C Jiménez-Romero, A Manrique Municio, E Marqués Medina, F Colina, P Ortega Domene, R Gómez Sanz, J C Meneu Diaz, M Abradelo de Usera, A Moreno Elola, E Moreno Gonzalez |
Journal | Transplantation proceedings
(Transplant Proc)
Vol. 38
Issue 8
Pg. 2505-7
(Oct 2006)
ISSN: 0041-1345 [Print] United States |
PMID | 17097982
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adult
- Humans
- Immunosuppressive Agents
(therapeutic use)
- Incidence
- Liver Diseases
(classification, surgery)
- Liver Diseases, Alcoholic
(classification, surgery)
- Liver Transplantation
(immunology)
- Neoplasms
(epidemiology)
- Postoperative Complications
(epidemiology)
- Retrospective Studies
- Skin Neoplasms
(epidemiology)
- Sunlight
(adverse effects)
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