Interleukin-10 - 1082 GG polymorphism influences the occurrence and the clinical characteristics of hepatitis C virus infection.

Abstract

BACKGROUND/AIMS:

In this study, we determined the genotypic and allelic frequencies of the Interleukin (IL)-10(-1082G/A) IL-10(-592A/C), and IL-10(-819C/T) polymorphisms, and their association with the risk to develop B cell Non Hodgkin Lymphoma (NHL) in hepatitis virus C (HCV) carriers.

RESULTS:

Genetic polymorphisms in the IL-10 gene promoter were studied in 250 consecutive patients with B-cell NHL with no clinical and/or laboratory findings of cryoglobulinemia, 142 NHL/HCV- and 108 NHL/HCV+ with chronic hepatitis (CH), 120 consecutive subjects with HCV-related CH, and 110 age, sex-matched healthy blood donors. The frequency of the IL-10(-1082GG) genotype vs remaining genotypes (IL-10(-1082GA/AA)) was higher in NHL/HCV+ patients than HCV-related CH patients (P=0.0002, OR=2.89, CI: 1.62-5.15) and in NHL/HCV+ than NHL/HCV- patients (P=0.0001, OR=2.99, CI: 1.72-5.19). Moreover, the IL-10(-1082GG) genotype was more prevalent in indolent NHL/HCV+ cases than aggressive NHL/HCV+ (P=0.0004, OR=4.97, CI: 2.10-11.79). Finally, we confirmed that IL-10(-1082GG) genotype is associated with higher IL-10 production compared to AA homozygous (P=0.037).

CONCLUSIONS:

The high IL-10 production, due to IL-10(-1082GG) genotype, influences the clinical expression of the HCV infection by increasing susceptibility to develop NHL and might contribute to the indolent form of the disease.

• Authors: Marcello Persico, Mario Capasso, Eliana Persico, Mario Masarone, Amalia de Renzo, Daniela Spano, Savino Bruno, Achille Iolascon
• Journal: Journal of hepatology (J Hepatol) Vol. 45 Issue 6 Pg. 779-85 (Dec 2006) ISSN: 0168-8278 [Print] Netherlands
• PMID: 17049666 (Publication Type: Journal Article)

Chemical References

• RNA, Viral
• Interleukin-10
• DNA

Topics

• Adult
• Aged
• Alleles
• DNA (genetics)
• Female
• Gene Frequency
• Genetic Predisposition to Disease
• Genotype
• Hepatitis C, Chronic (complications, epidemiology, genetics)
• Humans
• Interleukin-10 (biosynthesis, genetics)
• Lymphoma, B-Cell (epidemiology, etiology, genetics)
• Male
• Middle Aged
• Polymerase Chain Reaction
• Polymorphism, Genetic
• Prognosis
• RNA, Viral (analysis)
• Retrospective Studies
• Risk Factors