Glucose-lowering effect of powder formulation of African black tea extract in KK-A(y)/TaJcl diabetic mouse.

Abstract

We observed the suppressive effect of a powder formulation of African black tea extract prepared from the leaves of Camellia sinensis on type 2 non-insulin dependent diabetic mice, KK-A(y)/TaJcl. Black tea extract significantly showed suppressive effect of the elevation of blood glucose on oral glucose tolerance test of 8 week-old KK-A(y)/TaJcl mice (P < 0.05). Long-term treatment with black tea extract showed significant suppression of post-prandial blood glucose and obesity (P < 0.05). The weight of the intestine of mice treated with black tea extract was significantly reduced (P < 0.05). From these results, African black tea used in this study showed a suppressive effect on the elevation of blood glucose during food intake and the body weight.

• Authors: Yoko Shoji, Hideki Nakashima
• Journal: Archives of pharmacal research (Arch Pharm Res) Vol. 29 Issue 9 Pg. 786-94 (Sep 2006) ISSN: 0253-6269 [Print] Korea (South)
• PMID: 17024853 (Publication Type: Journal Article)

Chemical References

• Biomarkers
• Blood Glucose
• Hypoglycemic Agents
• Insulin
• Lipids
• Plant Extracts
• Powders
• Cholesterol

Topics

• 3T3 Cells
• Adipocytes (drug effects)
• Adipogenesis (drug effects)
• Animals
• Biomarkers
• Blood Glucose (metabolism)
• Body Weight (drug effects)
• Camellia sinensis (chemistry)
• Cell Differentiation (drug effects)
• Chemistry, Pharmaceutical
• Cholesterol (blood)
• Diabetes Mellitus (blood, drug therapy, genetics)
• Drinking (drug effects)
• Glucose Tolerance Test
• Hypoglycemic Agents (administration & dosage, pharmacology)
• Insulin (blood, pharmacology)
• Insulin Resistance (physiology)
• Lipids (blood)
• Male
• Mice
• Mice, Inbred Strains
• Plant Extracts (pharmacology)
• Powders