A randomized factorial study of the effects of long-term garlic and micronutrient supplementation and of 2-wk antibiotic treatment for Helicobacter pylori infection on serum cholesterol and lipoproteins.

Abstract

BACKGROUND:

Little is known about the long-term effects of garlic or micronutrient supplementation on total, HDL, and LDL cholesterol in disease-free persons.

OBJECTIVE:

We aimed to assess the effects of long-term supplementation with garlic and micronutrients and of short-term amoxicillin and omeprazole treatment on serum total, HDL, and LDL cholesterol in a rural Chinese population.

DESIGN:

We conducted a randomized, double-blind, placebo-controlled, 2 x 2 x 2 and 2 x 2 factorial study of precancerous gastric lesions in 3411 subjects in Linqu County, Shandong Province, China. Thirty-four subjects were randomly selected from each of 12 treatment strata. Sera were analyzed at 3.3 and 7.3 y to measure effects on total, HDL, and LDL cholesterol after 2-wk twice-daily treatment with 1 g amoxicillin and 20 mg omeprazole and supplementation throughout the study with 1) 2 capsules twice daily, each containing 200 mg aged garlic extract and 1 mg steam-distilled garlic oil, or 2) twice-daily micronutrient capsules containing 250 mg vitamin C, 100 IU vitamin E, and 37.5 mg selenium.

RESULTS:

Regressions adjusted for covariates indicated increases of 0.22 mmol total cholesterol/L (P = 0.01) and 0.19 mmol LDL/L (P = 0.02) after 7.3 y of micronutrient supplementation, but no effect of garlic supplementation or short-term amoxicillin and omeprazole treatment.

CONCLUSIONS:

In this rural Chinese population with low meat intake and moderate cholesterol concentrations, long-term garlic supplementation had no effect on lipid profiles, whereas micronutrient supplementation was associated with small but significant increases in total and LDL-cholesterol concentrations at 7.3 y.

• Authors: Lian Zhang, Mitchell H Gail, Yu-que Wang, Linda Morris Brown, Kai-feng Pan, Jun-ling Ma, Harunobu Amagase, Wei-Cheng You, Roxana Moslehi
• Journal: The American journal of clinical nutrition (Am J Clin Nutr) Vol. 84 Issue 4 Pg. 912-9 (Oct 2006) ISSN: 0002-9165 [Print] United States
• PMID: 17023720 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Anti-Bacterial Agents
• Anti-Ulcer Agents
• Cholesterol, HDL
• Cholesterol, LDL
• Lipoproteins
• Micronutrients
• Amoxicillin
• Cholesterol
• Omeprazole

Topics

• Amoxicillin (administration & dosage)
• Anti-Bacterial Agents (administration & dosage)
• Anti-Ulcer Agents (administration & dosage)
• China
• Cholesterol (blood)
• Cholesterol, HDL (blood)
• Cholesterol, LDL (blood)
• Dietary Supplements
• Double-Blind Method
• Drug Administration Schedule
• Factor Analysis, Statistical
• Female
• Garlic
• Helicobacter Infections (blood, drug therapy)
• Helicobacter pylori
• Humans
• Lipoproteins (blood, drug effects)
• Male
• Micronutrients (administration & dosage)
• Middle Aged
• Omeprazole (administration & dosage)
• Rural Population