Multiple myeloma associated with sialyl salivary-type amylase.
|
| Abstract | BACKGROUND: There have been several reports describing a notable hyperamylasaemia in patients with multiple myeloma. Such amylase-producing myelomas have been mainly described in the context of concomitant salivary-type hyperamylasaemia, with sialyl salivary-type amylase identified in a portion of those cases. We investigated the incidence of the production of sialyl salivary-type amylase in serum of multiple myeloma patients. METHODS: Eleven patients (6 male and 5 female) who had been diagnosed as having multiple myeloma were enrolled in this study. Sialyl salivary-type amylase was detected by isoamylase electrophoresis and HPLC analysis, and identified by detecting either abnormal neuraminidase-sensitive band through isoamylase electrophoresis or abnormal extra-elution peak of amylase by means of HPLC analysis. RESULTS: Sialyl salivary-type amylase was detected in 7 out of 11 (63.6%) patients. Median total amylase activity was 154 U/l (range 109-43020). Isoamylase electrophoretic patterns of patients' serum were normal in 5 patients (71.4%) out of 7 patients and salivary-dominant in 2 (50.0%) out of 4 patients. CONCLUSIONS: We consider that there is no significant relationship between total serum amylase level and amylase isoenzyme pattern in the incidence of production of sialyl salivary-type amylase with multiple myeloma.
|
|---|---|
| Authors | Masahiko Shigemura, Takanori Moriyama, Hitoshi Shibuya, Masato Obara, Tomoyuki Endo, Satoshi Hashino, Hiroshi Yokouchi, Masahiro Asaka, Chikara Shimizu, Hitoshi Chiba, Masaharu Nishimura |
| Journal | Clinica chimica acta; international journal of clinical chemistry (Clin Chim Acta) Vol. 376 Issue 1-2 Pg. 121-5 (Feb 2007) ISSN: 0009-8981 [Print] Netherlands |
| PMID | 16979610 (Publication Type: Journal Article) |
| Chemical References |
|
| Topics |
|
Join CureHunter, for free Research Interface BASIC access!
Realize the full power of the drug-disease research graph!