Retrospective analysis: concurrent chemoradiotherapy using protracted continuous infusion of low-dose cisplatin and 5-fluorouracil for T2N0 glottic cancer.

Abstract

PURPOSE:

Treatment with conventional radiotherapy alone for local control of T2 glottic cancer (T2GC) is insufficient. To improve local control of T2GC, we have simultaneously administered continuous intravenous infusions of low-dose cisplatin and 5-fluorouracil (5-FU) in combination with irradiation.

MATERIALS AND METHODS:

We performed this combination therapy in a total of 11 consecutive patients with previously untreated invasive squamous cell carcinoma (T2GC). Cisplatin was administered at 4 mg/m2/day and 5-FU at 200 mg/m2/day for 120 h, except during weekends, beginning on the day irradiation with a once-daily fraction at 2 Gy was started.

RESULTS:

An initial local control rate of the primary tumor was achieved in 10 of the 11 patients (91%), and ultimate laryngeal preservation by cordectomy was achieved in all cases. Regarding adverse reactions, grade 3 or 4 hemotoxicity did not develop in any of the patients. Grade 3 laryngitis was observed in four patients (36%), but none of these patients required interruption of treatment owing to acute laryngeal reactions.

CONCLUSION:

Instead of radiotherapy alone, this combination chemoradiotherapy is suggested with the possibility of improving local control of T2GCs.

• Authors: Yoshiyuki Itoh, Nobukazu Fuwa
• Journal: Radiation medicine (Radiat Med) Vol. 24 Issue 4 Pg. 277-81 (May 2006) ISSN: 0288-2043 [Print] Japan
• PMID: 16958401 (Publication Type: Journal Article)

Chemical References

• Cisplatin
• Fluorouracil

Topics

• Aged
• Antineoplastic Combined Chemotherapy Protocols (administration & dosage)
• Chemotherapy, Adjuvant (methods)
• Cisplatin (administration & dosage)
• Female
• Fluorouracil (administration & dosage)
• Humans
• Infusions, Intravenous
• Laryngeal Neoplasms (drug therapy, radiotherapy)
• Male
• Middle Aged
• Neoplasms, Squamous Cell (drug therapy, radiotherapy)
• Retrospective Studies
• Treatment Outcome
• Vocal Cords (drug effects, radiation effects)