Plasma natriuretic peptide levels reflect changes in heart failure symptoms, left ventricular size and function after surgical mitral valve repair.

Abstract

BACKGROUND AND AIM:

N-terminal pro-B-type natriuretic peptide (NT-proBNP) has diagnostic and prognostic value in patients with heart failure. The present prospective study was designed to assess whether changes in NT-proBNP levels after surgical mitral valve repair reflect changes in heart failure symptoms and changes in left atrial size, left ventricular size and left ventricular function.

METHODS:

The study population consisted of 22 patients (mean age: 62.8 +/- 14.2 years, 68% male) undergoing surgical mitral valve repair. Serial NT-proBNP measurements, transthoracic echocardiography and New York Heart Association (NYHA) class assessment were performed before and 6 months after surgery.

RESULTS:

All patients underwent successful mitral valve repair and no patients died during follow-up. The decrease in NT-proBNP level was associated with the reduction in left atrial dimension (r = 0.72, P < 0.001), left ventricular end-systolic dimension (r = 0.63, P = 0.002), left ventricular end-diastolic dimension (r = 0.46, P = 0.031), and the increase in fractional shortening (r = - 0.63, P = 0.002). Finally, patients with decreasing NT-proBNP levels revealed a significant improvement in heart failure symptoms (NYHA class).

CONCLUSION:

Changes in NT-proBNP after surgical mitral valve repair reflect changes in heart failure symptoms and changes in left atrial and ventricular dimensions and function.

• Authors: Harm H H Feringa, Don Poldermans, Patrick Klein, Jerry Braun, Robert J M Klautz, Ron T van Domburg, Arnoud van der Laarse, Ernst E van der Wall, Robert A E Dion, Jeroen J Bax
• Journal: The international journal of cardiovascular imaging (Int J Cardiovasc Imaging) Vol. 23 Issue 2 Pg. 159-65 (Apr 2007) ISSN: 1569-5794 [Print] United States
• PMID: 16941223 (Publication Type: Journal Article)

Chemical References

• Biomarkers
• Peptide Fragments
• pro-brain natriuretic peptide (1-76)
• Natriuretic Peptide, Brain

Topics

• Aged
• Biomarkers (blood)
• Diastole
• Echocardiography, Transesophageal
• Female
• Follow-Up Studies
• Heart Atria (diagnostic imaging)
• Heart Failure (blood, etiology, pathology, physiopathology, surgery)
• Heart Ventricles (diagnostic imaging)
• Humans
• Male
• Middle Aged
• Mitral Valve (surgery)
• Mitral Valve Insufficiency (blood, complications, physiopathology, surgery)
• Myocardial Contraction
• Natriuretic Peptide, Brain (blood)
• Organ Size
• Peptide Fragments (blood)
• Prognosis
• Prospective Studies
• Severity of Illness Index
• Systole
• Time Factors
• Treatment Outcome
• Ventricular Function, Left
• Ventricular Remodeling