Abstract | OBJECTIVE: To determine the effect of continuous IV administration of 50% dextrose solution on phosphorus homeostasis in lactating dairy cows. DESIGN: Clinical trial. ANIMALS: 4 multiparous Jersey cows. PROCEDURES: RESULTS: Plasma glucose, IRI, and phosphorus concentrations were stable during sham treatment. Plasma phosphorus concentration decreased rapidly after onset of dextrose infusion, reaching a nadir in 24 hours and remaining less than baseline value for 36 hours. Plasma phosphorus concentration increased after dextrose infusion was stopped, peaking in 6 hours. Urinary phosphorus excretion did not change during dextrose infusion, but phosphorus intake decreased because of reduced feed intake, followed by decreased fecal phosphorus loss and milk yield. Rapid changes in plasma phosphorus concentration at the start and end of dextrose infusion were temporally associated with changes in plasma glucose and IRI concentrations and most likely caused by compartmental shifts of phosphorus. CONCLUSIONS AND CLINICAL RELEVANCE:
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Authors | Walter Grünberg, Dawn E Morin, James K Drackley, Anne M Barger, Peter D Constable |
Journal | Journal of the American Veterinary Medical Association
(J Am Vet Med Assoc)
Vol. 229
Issue 3
Pg. 413-20
(Aug 01 2006)
ISSN: 0003-1488 [Print] United States |
PMID | 16881835
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Blood Glucose
- Insulin
- Phosphorus
- Glucose
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Topics |
- Animals
- Area Under Curve
- Blood Glucose
(metabolism)
- Cattle
(metabolism)
- Dairying
- Feces
(chemistry)
- Female
- Glucose
(administration & dosage, pharmacology)
- Homeostasis
(drug effects)
- Infusions, Intravenous
(veterinary)
- Insulin
(metabolism)
- Kinetics
- Lactation
(metabolism)
- Milk
(chemistry, metabolism)
- Phosphorus
(analysis, blood, metabolism, pharmacokinetics)
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