Abstract | OBJECTIVES: The objective of the present study was to assess the in vitro and in vivo activities of DW-224a in order to eventually use it as an antibiotic. METHODS: RESULTS: Against Gram-positive bacteria, the in vitro activity of DW-224a was stronger than those of ciprofloxacin and trovafloxacin, but slightly weaker than that of DW286. Against Gram-negative bacteria, the activity of DW-224a was similar to those of trovafloxacin and DW286, but weaker than that of ciprofloxacin. In experimental systemic infections in mice with various organisms, like DW286, DW-224a demonstrated potent activity against Gram-positive bacteria and somewhat less activity against Gram-negative bacteria. CONCLUSIONS:
DW-224a has a broad spectrum of antimicrobial activity, which is especially potent against Gram-positive bacteria.
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Authors | Ae-Ran Kwon, Yu-Hong Min, Jei-Man Ryu, Dong-Rack Choi, Mi-Ja Shim, Eung-Chil Choi |
Journal | The Journal of antimicrobial chemotherapy
(J Antimicrob Chemother)
Vol. 58
Issue 3
Pg. 684-8
(Sep 2006)
ISSN: 0305-7453 [Print] England |
PMID | 16873394
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Bacterial Agents
- Fluoroquinolones
- zabofloxacin
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Topics |
- Administration, Oral
- Animals
- Anti-Bacterial Agents
(administration & dosage, pharmacology, therapeutic use)
- Fluoroquinolones
(administration & dosage, pharmacology, therapeutic use)
- Gram-Negative Bacteria
(drug effects, isolation & purification)
- Gram-Negative Bacterial Infections
(drug therapy)
- Gram-Positive Bacteria
(drug effects, isolation & purification)
- Gram-Positive Bacterial Infections
(drug therapy)
- Humans
- Male
- Mice
- Mice, Inbred ICR
- Microbial Sensitivity Tests
- Molecular Structure
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