High-dose-rate brachytherapy without external beam irradiation for locally advanced prostate cancer.

Abstract

BACKGROUND AND PURPOSE:

High-dose-rate brachytherapy (HDR-BT) had been used only in combination with external beam irradiation (EBI) until our previously reported first trial of HDR-BT alone without EBI. The purpose of the current report is to evaluate the feasibility, toxicity and efficacy of this regimen, with more patient accrual and longer follow-up.

MATERIAL AND METHODS:

From 1995 through 2004, 111 patients with localized prostate cancer were treated with HDR-BT without EBI. Fifteen patients were considered as low-risk, 28 as intermediate-risk, and 68 as high-risk. The prescribed dose was 48 Gy/8 fractions/5 days or 54 Gy/9 fractions/5 days. Median follow-up time was 27 months (range 5-119).

RESULTS:

All the patients completed the treatment regimen. The 3- and 5-year PSA failure-free rates were 83% and 70%, and the local control rates 100% and 97%. The maximum toxicities observed were Grade 3 by CTCAE v3.0 (6 acute, 1 chronic).

CONCLUSIONS:

HDR-BT without EBI was feasible and its toxicity acceptable. Short-term tumor control was promising, even for locally advanced cases. More patient accrual and longer follow-up are needed to confirm the efficacy of this novel approach.

• Authors: Yasuo Yoshioka, Koji Konishi, Ryoong-Jin Oh, Iori Sumida, Hideya Yamazaki, Satoaki Nakamura, Kazuo Nishimura, Norio Nonomura, Akihiko Okuyama, Takehiro Inoue
• Journal: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology (Radiother Oncol) Vol. 80 Issue 1 Pg. 62-8 (Jul 2006) ISSN: 0167-8140 [Print] Ireland
• PMID: 16870289 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Prostate-Specific Antigen

Topics

• Aged
• Aged, 80 and over
• Brachytherapy (methods)
• Disease-Free Survival
• Follow-Up Studies
• Humans
• Male
• Middle Aged
• Prostate-Specific Antigen (biosynthesis)
• Prostatic Neoplasms (pathology, radiotherapy)
• Radiometry
• Radiotherapy (methods)
• Risk
• Time Factors
• Treatment Outcome