[Inhibition of quercetin on liver fibrosis due to Schistosoma japonicum infection and on the expression of immediate early gene and metalloproteinase 1 inhibitor in liver tissue of mice].

Abstract

Quercetin and praziquantel were used to treat mice with hepatic fibrosis due to Schistosoma japonicum infection. Quercetin treatment obviously relieved the degree of hepatic fibrosis, significantly reduced the expression of immediate early gene, tissue inhibitor of metalloproteinase 1 (TIMP 1), types I and III collagen compared to the control. The expression of c-jun mRNA, type I and type III collagen were reduced significantly compared to the group treated with praziquantel, whereas no difference in the expression of c-fos mRNA and TIMP1 between the two groups, indicating that quercetin may have better effect on schistosomal liver fibrosis than praziquantel in the long term.

• Authors: Biao Xu, Sheng-song He, Chun-rong Han
• Journal: Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases (Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi) Vol. 24 Issue 2 Pg. 148-9 (Apr 30 2006) ISSN: 1000-7423 [Print] China
• PMID: 16862918 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antioxidants
• Collagen Type I
• Collagen Type III
• RNA, Messenger
• Tissue Inhibitor of Metalloproteinase-1
• Quercetin

Topics

• Animals
• Antioxidants (pharmacology, therapeutic use)
• Collagen Type I (biosynthesis)
• Collagen Type III (biosynthesis)
• Female
• Fibrosis (etiology)
• Gene Expression (drug effects)
• Genes, Immediate-Early (genetics)
• Immunohistochemistry
• Liver (drug effects, metabolism, pathology)
• Mice
• Mice, Inbred Strains
• Quercetin (pharmacology, therapeutic use)
• RNA, Messenger (genetics, metabolism)
• Reverse Transcriptase Polymerase Chain Reaction
• Schistosoma japonicum (drug effects)
• Schistosomiasis japonica (complications, drug therapy, parasitology)
• Tissue Inhibitor of Metalloproteinase-1 (biosynthesis)