Seroprotection against diphtheria and tetanus among Russian and Norwegian teenagers.

Abstract

Russian children between 7 and 10 years of age have been shown to have significantly higher seroprotection against diphtheria compared to Norwegian children. That was due to a reinforcing dose given on entering school to Russian but not to Norwegian children. The next booster was given at the age of 11-12 years in both countries. We have compared diphtheria and tetanus antitoxin levels among 13- to 14- and 15- to 16-year-old teenagers to see if the difference was maintained among the older age group. Serum samples obtained from 106 Russian and 117 Norwegian teenagers were tested by enzyme immunoassay. The Russian and Norwegian adolescents exhibited adequate rates of protection against diphtheria with similar geometric mean antitoxin concentrations of 1.26 and 1.15 IU/ml, respectively, at 13-14 years, and 0.33 and 0.29 IU/ml at 15-16 years. Differences within the age groups were not significant. However, at 13-14 years the Norwegians were much better protected 2 years after a reinforcing dose of tetanus toxoid than the Russians who had not been boosted for 7 years. At the age of 15-16 the difference diminished and became statistically not significant.

• Authors: Elena Danilova, Alexey Shiryayev, Einar Klaeboe Kristoffersen, Haakon Sjursen
• Journal: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica (APMIS) Vol. 114 Issue 6 Pg. 453-7 (Jun 2006) ISSN: 0903-4641 [Print] Denmark
• PMID: 16856968 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Diphtheria Antitoxin
• Diphtheria-Tetanus Vaccine
• Tetanus Antitoxin

Topics

• Adolescent
• Diphtheria (blood, epidemiology, prevention & control)
• Diphtheria Antitoxin (blood)
• Diphtheria-Tetanus Vaccine (administration & dosage)
• Humans
• Immunization Schedule
• Norway (epidemiology)
• Russia (epidemiology)
• Seroepidemiologic Studies
• Tetanus (blood, epidemiology, prevention & control)
• Tetanus Antitoxin (blood)