Decrease in triglyceride level by bezafibrate is related to reduction of recurrent coronary events: a Bezafibrate Infarction Prevention substudy.

Abstract

BACKGROUND:

Fibrates were reported to be effective in reducing recurrent coronary events in coronary heart disease patients with elevated triglycerides. It is not known whether this effect is related to the extent of triglyceride reduction.

METHODS:

Participants comprised 3090 coronary heart disease patients enrolled in the Bezafibrate Infarction Prevention study, which showed a nonsignificant reduction (9.4%; P=0.26) in fatal or nonfatal myocardial infarction and sudden death during a mean follow-up time of 6.2 years.

RESULTS:

Significant reduction in triglyceride serum level was evident only among patients allocated to bezafibrate, ranging between 0.06 mmol/l (5 mg/dl) in the lowest decile of baseline triglycerides level and 0.68 mmol/l (60 mg/dl) in the highest baseline decile. The extent of triglyceride reduction with bezafibrate was significantly associated with the reduction of risk; relative risk reduction of 55% (hazards ratio: 0.45; 95% confidence interval: 0.24-0.84) was observed among patients with baseline triglycerides>or=2.26 mmol/l who reduced triglyceride level to >0.50 mmol/l (>44.3 mg/dl). In contrast, the risk of recurrent events among patients treated with bezafibrate and achieving less triglyceride reduction or failing to reduce triglyceride level was not significantly different from that of patients treated with placebo.

CONCLUSION:

Bezafibrate treatment was associated with significant risk reduction among coronary heart disease patients with elevated triglyceride levels that substantially reduced their triglyceride level with treatment.

• Authors: Moti Haim, Michal Benderly, Valentina Boyko, Ilan Goldenberg, David Tanne, Alex Battler, Uri Goldbourt, Solomon Behar, Bezafibrate Infarction Prevention (BIP) Study Group
• Journal: Coronary artery disease (Coron Artery Dis) Vol. 17 Issue 5 Pg. 455-61 (Aug 2006) ISSN: 0954-6928 [Print] England
• PMID: 16845254 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Hypolipidemic Agents
• Triglycerides
• Clofibric Acid
• Bezafibrate

Topics

• Aged
• Bezafibrate (pharmacology, therapeutic use)
• Clofibric Acid (pharmacology, therapeutic use)
• Female
• Humans
• Hypertriglyceridemia (drug therapy)
• Hypolipidemic Agents (pharmacology, therapeutic use)
• Male
• Middle Aged
• Prospective Studies
• Risk Assessment
• Risk Factors
• Secondary Prevention
• Triglycerides (blood)