Abstract | BACKGROUND: OBJECTIVE: METHODS: The scoring atopic dermatitis (SCORAD) instrument and visual analogue scale (VAS) for pruritus were used to assess disease severity in 349 AD patients. Twenty patients with moderate AD symptoms, who had not received any treatment for 2 weeks, were randomly assigned into two groups. Ten patients underwent fexofenadine and emollient treatment (Group 1) and 10 received fexofenadine and steroid treatment (Group 2) for 1 week. SCORAD and VAS for pruritus, and blood histamine and tryptase levels were evaluated before and after treatment. RESULTS: SCORAD and VAS improved in both Group 1 (p=0.01 and p=0.006, respectively) and Group 2 (p<0.001 and p=0.001, respectively). The improvement in Group 1 showed a significant correlation with the diminution rate of blood tryptase levels (SCORAD: r=0.83 and p=0.013, respectively; VAS: r=0.81, p=0.015, respectively). End-point plasma tryptase levels were significantly lower than baseline levels in Group 2 (p=0.046). Histamine levels did not show any significant changes in either group. CONCLUSION:
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Authors | Tamihiro Kawakami, Kyoko Kaminishi, Yoshinao Soma, Tsuneto Kushimoto, Masako Mizoguchi |
Journal | Journal of dermatological science
(J Dermatol Sci)
Vol. 43
Issue 2
Pg. 127-34
(Aug 2006)
ISSN: 0923-1811 [Print] Netherlands |
PMID | 16843643
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Histamine H1 Antagonists
- Serine Endopeptidases
- Tryptases
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Topics |
- Administration, Oral
- Adult
- Asthma
(complications)
- Conjunctivitis
(complications)
- Dermatitis, Atopic
(blood, drug therapy, immunology)
- Female
- Histamine H1 Antagonists
(administration & dosage, adverse effects, therapeutic use)
- Humans
- Male
- Rhinitis, Allergic, Perennial
(complications)
- Safety
- Serine Endopeptidases
(blood)
- Treatment Outcome
- Tryptases
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