Abstract | BACKGROUND: AIM: METHODS: Children with cholestasis received 30 mg/kg/day UDCA. Improvement or normalization of parenteral nutrition-associated cholestasis was evaluated at 6 months of therapy and at the last follow-up. In a subgroup of children, serum UDCA levels were measured while receiving UDCA and after 4 weeks withdrawal. RESULTS: Twelve children were treated with UDCA. Full remission or partial improvement of parenteral nutrition-associated cholestasis occurred in 11 of 12 children. In three of four children, withdrawal of UDCA was associated with a rebound rise of cholestasis. Only one of 12 treated children showed no improvement and in this patient, in contrast to four other patients, plasma levels of UDCA did not increase during treatment. CONCLUSIONS:
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Authors | G De Marco, D Sordino, E Bruzzese, S Di Caro, D Mambretti, A Tramontano, C Colombo, P Simoni, A Guarino |
Journal | Alimentary pharmacology & therapeutics
(Aliment Pharmacol Ther)
Vol. 24
Issue 2
Pg. 387-94
(Jul 15 2006)
ISSN: 0269-2813 [Print] England |
PMID | 16842466
(Publication Type: Journal Article)
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Chemical References |
- Cholagogues and Choleretics
- Ursodeoxycholic Acid
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Topics |
- Cholagogues and Choleretics
(therapeutic use)
- Cholestasis
(drug therapy, etiology)
- Humans
- Infant
- Infant, Newborn
- Intestinal Diseases
(blood, therapy)
- Parenteral Nutrition
(adverse effects)
- Treatment Outcome
- Ursodeoxycholic Acid
(blood, therapeutic use)
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