Spotlight on tNOX: a tumor-selective target for cancer therapies.

Abstract

Tumor-associated NOX (tNOX) is a novel cell surface ECTO-NOX protein that represents a promising target for selective antitumor therapy. Studies have confirmed the unique presence of tNOX on the cell surface of invasive human cancers and in the sera of cancer patients. Furthermore, as there is a resolute difference between tNOX and the drug-resistant constitutive NOX isoform constitutive NOX, it represents an attractive target for drug, vaccine and diagnostic strategies for cancer. Interestingly, several products currently utilized or under development for cancer display tNOX inhibition as one of their underlying mechanisms, these include non- steroidal antiinflammatory drugs, (-)-epigallocatechin gallate, phenoxodiol and doxorubicin hydrochloride (Adria- mycin). This spotlight article will also highlight tNOX inhibitors under preclinical development and new lines of research to target tNOX for cancer therapeutics.

• Authors: Shelley L Davies, Jordi Bozzo
• Journal: Drug news & perspectives (Drug News Perspect) Vol. 19 Issue 4 Pg. 223-5 (May 2006) ISSN: 0214-0934 [Print] United States
• PMID: 16823496 (Publication Type: Journal Article, Review)
• Copyright: Copyright 2006 Prous Science

Chemical References

• Antineoplastic Agents
• NADH, NADPH Oxidoreductases
• tumor-associated NADH oxidase

Topics

• Antineoplastic Agents (therapeutic use)
• Drug Delivery Systems
• Humans
• NADH, NADPH Oxidoreductases (drug effects, genetics)
• Neoplasms (drug therapy, genetics)