Abstract | OBJECTIVES: BACKGROUND:
Atherosclerosis is a chronic immuno-inflammatory disease wherein both oxidized lipids and infectious agents are incriminated as possible contributors. METHODS: RESULTS: The OxLDL-AB and ApoB-IC levels remained stable over time as indicated by strong correlations between 1995 and 2000 measurements (p < 0.001 each). Significant associations existed between all OxLDL markers and antibody titers to pathogens, especially to E. coli-LPS and mHSP65. Both OxLDL-AB and ApoB-IC levels showed a rise with increasing pathogen burden. Notably, OxLDL-ABs were also elevated in subjects with chronic infection as defined by clinical criteria. Titers of IgG, but not IgM, OxLDL-AB, or ApoB-IC inversely correlated with total cholesterol, LDL cholesterol, and apoB concentrations. The IgG OxLDL markers were positively and IgM markers were inversely associated with incident and progressive carotid atherosclerosis in univariate analyses but were not independent predictors in multivariate analyses. CONCLUSIONS:
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Authors | Manuel Mayr, Stefan Kiechl, Sotirios Tsimikas, Elizabeth Miller, Joanna Sheldon, Johann Willeit, Joseph L Witztum, Qingbo Xu |
Journal | Journal of the American College of Cardiology
(J Am Coll Cardiol)
Vol. 47
Issue 12
Pg. 2436-43
(Jun 20 2006)
ISSN: 1558-3597 [Electronic] United States |
PMID | 16781371
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Autoantibodies
- Lipoproteins, LDL
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Topics |
- Adult
- Aged
- Autoantibodies
(metabolism)
- Carotid Artery Diseases
(complications, immunology, metabolism)
- Chronic Disease
- Female
- Humans
- Infections
(complications, immunology, metabolism)
- Lipoproteins, LDL
(immunology)
- Male
- Middle Aged
- Oxidation-Reduction
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