Abstract | BACKGROUND: MATERIALS AND METHODS: Coronary ligation area and area of no-reflow were determined with both myocardial contrast echocardiography in vivo and histopathological evaluation in 44 Yorkshire mini-swines randomized into five study groups: ten in control, eight in adenosine-treated, nine in diltiazem-treated, nine in verapamil-treated and eight in sham-operated. An acute myocardial infarction and reperfusion model was created with 3-h occlusion of the left anterior descending coronary artery followed by 1-h reperfusion. RESULTS: CONCLUSIONS: These findings support the concept that adenosine can reduce both structural and functional no-reflow, while calcium channel blockade can only reduce functional no-reflow.
|
Authors | Jing-Lin Zhao, Yue-Jin Yang, Chuan-Jue Cui, Shi-Jie You, Yong-Jian Wu, Run-Lin Gao |
Journal | Cardiovascular drugs and therapy
(Cardiovasc Drugs Ther)
Vol. 20
Issue 3
Pg. 167-75
(Jun 2006)
ISSN: 0920-3206 [Print] United States |
PMID | 16775665
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Antigens, CD
- Cadherins
- Calcium Channel Blockers
- RNA, Messenger
- beta Catenin
- cadherin 5
- gamma Catenin
- Adenosine
|
Topics |
- Adenosine
(pharmacology)
- Animals
- Antigens, CD
(analysis, genetics)
- Cadherins
(analysis, genetics)
- Calcium Channel Blockers
(pharmacology)
- Coronary Circulation
(drug effects)
- Myocardial Infarction
(drug therapy, physiopathology)
- Myocardial Reperfusion Injury
(prevention & control)
- Myocardium
(metabolism)
- RNA, Messenger
(analysis)
- Swine
- Swine, Miniature
- beta Catenin
(analysis, genetics)
- gamma Catenin
(analysis, genetics)
|