Development of a linear type of low molecular weight CXCR4 antagonists based on T140 analogs.

Abstract

A linear type of several low molecular weight CXCR4 antagonists were developed based on T140 analogs, which were previously found to be strong CXCR4 antagonists that block X4-HIV-1 entry and have inhibitory activities against cancer metastasis/progression and rheumatoid arthritis.

• Authors: Hirokazu Tamamura, Hiroshi Tsutsumi, Hiroyuki Masuno, Satoko Mizokami, Kenichi Hiramatsu, Zixuan Wang, John O Trent, Hideki Nakashima, Naoki Yamamoto, Stephen C Peiper, Nobutaka Fujii
• Journal: Organic & biomolecular chemistry (Org Biomol Chem) Vol. 4 Issue 12 Pg. 2354-7 (Jun 21 2006) ISSN: 1477-0520 [Print] England
• PMID: 16763678 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-HIV Agents
• Antineoplastic Agents
• Oligopeptides
• Peptides, Cyclic
• Receptors, CXCR4
• T140 peptide

Topics

• Anti-HIV Agents (chemical synthesis, chemistry, pharmacology)
• Antineoplastic Agents (chemical synthesis, chemistry, pharmacology)
• Cell Line
• Humans
• Molecular Weight
• Oligopeptides (chemistry, pharmacology)
• Peptides, Cyclic (chemical synthesis, chemistry, pharmacology)
• Receptors, CXCR4 (antagonists & inhibitors)