Abstract | PURPOSE: METHODS: This was a multicenter, prospective, randomized, double-masked, parallel group clinical study of 92 patients with open-angle glaucoma (with or without pseudoexfoliative or pigmentary glaucoma) or ocular hypertension. After a washout of existing glaucoma medications, patients were randomly assigned to receive one drop of travoprost 0.004%/ timolol 0.5% in the morning or evening for 6 weeks. The main outcome measures were mean intraocular pressure (IOP) assessed at 9 am, 11 am, and 4 pm, and safety variables. RESULTS:
Travoprost 0.004%/ timolol 0.5% ophthalmic solution, dosed in the morning or evening, controlled IOP consistently throughout the day. Mean IOP ranged from 16.5 to 16.7 mmHg in the morning treatment group and from 16.1 to 17.2 mmHg in the evening treatment group. Travoprost 0.004%/ timolol 0.5% ophthalmic solution produced statistically significant and clinically relevant reductions in IOP from baseline; mean reductions ranged from approximately 8 to 10 mmHg (32% to 38%). Travoprost 0.004%/ timolol 0.5% ophthalmic solution was safe and well tolerated with the most frequently reported adverse event being ocular hyperemia, which occurred in 12.5% of patients in the morning treatment group and 13.6% of patients in the evening treatment group. CONCLUSIONS:
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Authors | P Denis, R Andrew, D Wells, B Friren |
Journal | European journal of ophthalmology
(Eur J Ophthalmol)
2006 May-Jun
Vol. 16
Issue 3
Pg. 407-15
ISSN: 1120-6721 [Print] United States |
PMID | 16761242
(Publication Type: Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antihypertensive Agents
- Ophthalmic Solutions
- Cloprostenol
- Timolol
- Travoprost
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Antihypertensive Agents
(administration & dosage, adverse effects)
- Cloprostenol
(administration & dosage, adverse effects, analogs & derivatives)
- Double-Blind Method
- Drug Administration Schedule
- Drug Therapy, Combination
- Female
- Glaucoma, Open-Angle
(drug therapy)
- Humans
- Intraocular Pressure
(drug effects)
- Male
- Middle Aged
- Ocular Hypertension
(drug therapy)
- Ophthalmic Solutions
(administration & dosage, adverse effects)
- Prospective Studies
- Timolol
(administration & dosage, adverse effects)
- Travoprost
- Treatment Outcome
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