Association analysis of delta-opioid receptor gene polymorphisms in methamphetamine dependence/psychosis.
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| Abstract |
The role of the delta-opioid receptor (OPRD1) in methamphetamine (MAP) addiction was investigated using association analysis between OPRD1 gene polymorphisms and MAP dependence/psychosis. DNA samples from Japanese patients with MAP dependence/psychosis were analyzed to find polymorphisms in OPRD1 gene exons and exon-intron boundaries. One novel single nucleotide polymorphism (SNP) in intron 1 and two SNPs in exon 3 were identified. The two SNPs in exon 3 were in linkage disequilibrium. No significant difference was observed in either genotypic or allelic frequencies of these SNPs between controls (n = 260) and MAP dependent/psychotic patients (n = 170). Global analyses using the three SNPs and subcategory analyses on clinical parameters also showed no significant differences. These results suggest that the OPRD1 gene variants may not be a factor in vulnerability to MAP dependence/psychosis.
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| Authors | Hideaki Kobayashi, Harumi Hata, Hiroshi Ujike, Mutsuo Harano, Toshiya Inada, Tokutaro Komiyama, Mitsuhiko Yamada, Yoshimoto Sekine, Nakao Iwata, Masaomi Iyo, Norio Ozaki, Masanari Itokawa, Maki Naka, Soichiro Ide, Kazutaka Ikeda, Yohtaro Numachi, Ichiro Sora |
| Journal | American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics (Am J Med Genet B Neuropsychiatr Genet) Vol. 141B Issue 5 Pg. 482-6 (Jul 05 2006) ISSN: 1552-4841 [Print] United States |
| PMID | 16741914 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
| Copyright | (c) 2006 Wiley-Liss, Inc. |
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