[Evaluation on the visual inspection with Lugol's iodine in cervical cancer screening program].

Abstract

OBJECTIVE:

To evaluate visual inspection with Lugol's iodine (VILI) in cervical cancer screening program and to provide evidence for designing a cervical cancer screening algorithm in high risk areas of existing low-resource settings to reduce the incidence and mortality of cervical cancer.

METHODS:

Women in Yangcheng county, Shanxi province were screened with VILI, colposcopy, liquid-based cytology test and human papilloma virus (HPV) DNA test. The efficacy of different screening tests was compared by Youden's index based on the pathology as the gold standard.

RESULTS:

In the population being screened, the mean age was 40.80 +/- 10.75 years old. Based on pathological findings, 4.35% (32/735) of the subjects had >or= CIN (cervical intraepithelial neoplasia) II. The sensitivity and specificity for the VILI test (>or= positive) were 53.13 and 82.19, while 56.25 and 79.09 were for colposcopy (>or= low grade dysplasia) respectively. Comparing by the Youden's indexs, there was no statistically significant difference (P > 0.05) between VILI and colposcopy. However, statistical significant difference (P < 0.05) was found between VILI and liquid-based cytology test and HPV DNA test. In addition, there was no statistically significant difference (P > 0.05) found between the experienced doctors and the newly-trained doctors working in the field station.

CONCLUSION:

With low sensitivity when using microscope but low cost of equipments, VILI can be one of the primary screening tests in China's rural area with low-resource settings if the screening frequency is to be increased.

• Authors: Ni Li, Cong-ping Ma, Li-xin Sun, Yong-zhen Zhang, Shu-li Shao, Ju-xia Xing, Yan-ping Bao, Rui-de Huang, Li-ji He, You-lin Qiao
• Journal: Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi (Zhonghua Liu Xing Bing Xue Za Zhi) Vol. 27 Issue 1 Pg. 15-8 (Jan 2006) ISSN: 0254-6450 [Print] China
• PMID: 16737565 (Publication Type: Evaluation Study, Journal Article)

Chemical References

• Iodides
• Lugol's solution

Topics

• Adult
• China (epidemiology)
• Early Detection of Cancer (economics, methods)
• Female
• Health Resources
• Humans
• Incidence
• Iodides
• Program Evaluation
• Rural Health
• Sensitivity and Specificity
• Socioeconomic Factors
• Uterine Cervical Neoplasms (diagnosis, epidemiology)
• Uterine Cervical Dysplasia (diagnosis, epidemiology)