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Phosphonoacetic acid-resistant herpes simplex virus infection in hairless mice.

Abstract
Phosphonoacetic acid (PAA)-resistant type 1 herpes simplex virus population was isolated by repeated passage of the virus in the presence of this inhibitor. Hairless mice infected percutaneously with the inhibitor-resistant or the parental inhibitor-susceptible virus were treated intraperitoneally with PAA and 9-beta-d-arabinofuranosyl-adenine by using several different dosage schedules. Whereas 9-beta-d-arabinofuranosyl-adenine was effective both in the PAA-susceptible and PAA-resistant herpes simplex virus-induced skin infection, PAA suppressed only the infection induced by the parental PAA-susceptible virus.
AuthorsR J Klein, A E Friedman-Kien
JournalAntimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 7 Issue 3 Pg. 289-93 (Mar 1975) ISSN: 0066-4804 [Print] United States
PMID166611 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Acetates
  • Antiviral Agents
  • Organophosphonates
Topics
  • Acetates (therapeutic use)
  • Animals
  • Antiviral Agents (therapeutic use)
  • Drug Resistance, Microbial
  • Herpes Simplex (drug therapy)
  • Mice
  • Organophosphonates (therapeutic use)
  • Simplexvirus

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