Abstract |
Phosphonoacetic acid (PAA)-resistant type 1 herpes simplex virus population was isolated by repeated passage of the virus in the presence of this inhibitor. Hairless mice infected percutaneously with the inhibitor-resistant or the parental inhibitor-susceptible virus were treated intraperitoneally with PAA and 9-beta-d-arabinofuranosyl-adenine by using several different dosage schedules. Whereas 9-beta-d-arabinofuranosyl-adenine was effective both in the PAA-susceptible and PAA-resistant herpes simplex virus-induced skin infection, PAA suppressed only the infection induced by the parental PAA-susceptible virus.
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Authors | R J Klein, A E Friedman-Kien |
Journal | Antimicrobial agents and chemotherapy
(Antimicrob Agents Chemother)
Vol. 7
Issue 3
Pg. 289-93
(Mar 1975)
ISSN: 0066-4804 [Print] United States |
PMID | 166611
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Acetates
- Antiviral Agents
- Organophosphonates
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Topics |
- Acetates
(therapeutic use)
- Animals
- Antiviral Agents
(therapeutic use)
- Drug Resistance, Microbial
- Herpes Simplex
(drug therapy)
- Mice
- Organophosphonates
(therapeutic use)
- Simplexvirus
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