Exploring a new twist on tumor metastasis.

Abstract	Unraveling the genetic programs that drive -metastasis may offer insights into how to limit or prevent this deadly aspect of cancer progression. Our recent studies indicate that tumor cell metastasis involves the activity of the transcription factor, Twist, which regulates epithelial-mesenchymal transition and early embryonic morphogenesis. Here, we review the Twist signaling pathway during normal development and discuss how the transcription factor Twist and the epithelial-mesenchymal transition program impinge their biological functions during tumor metastasis.
Authors	Jing Yang, Sendurai A Mani, Robert A Weinberg
Journal	Cancer research (Cancer Res) Vol. 66 Issue 9 Pg. 4549-52 (May 01 2006) ISSN: 0008-5472 [Print] United States
PMID	16651402 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)
Chemical References	RNA, Messenger Twist-Related Protein 1
Topics	Animals Epithelial Cells (pathology) Gene Expression Profiling Humans Mesoderm (pathology) Neoplasm Metastasis Neoplasms (genetics, pathology) RNA, Messenger (biosynthesis, genetics) Signal Transduction Twist-Related Protein 1 (biosynthesis, genetics, physiology)

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