The presence of anti-phosphatidylserine/prothrombin antibodies as risk factor for both arterial and venous thrombosis in patients with systemic lupus erythematosus.

Abstract	In an effort to clarify the clinical significance of anti-phospholipid antibodies (aPL) detected by enzyme-linked immunosorbent assay (ELISA), we examined the prevalence of anti-cardiolipin antibodies (aCL), anti-beta2-glycoprotein I antibodies (anti-beta2-GPI), antiprothrombin antibodies (anti-PT), and anti-phosphatidylserine/prothrombin antibodies (anti-PS/PT) in 175 patients with systemic lupus erythematosus (SLE) comprising 67 patients with thrombotic complications. The present study showed that positive results of anti-beta2-GPI-ELISA and anti-PS/PT-ELISA could serve as markers of thrombotic complications in patients with SLE, whereas aCL and anti-PT are less reliable as markers of these complications. Furthermore, results of the anti-PS/PT-ELISA correlate best with the occurrence of both arterial and venous thrombosis in patients with SLE.
Authors	Junzo Nojima, Yoshinori Iwatani, Etsuji Suehisa, Hirohiko Kuratsune, Yuzuru Kanakura
Journal	Haematologica (Haematologica) Vol. 91 Issue 5 Pg. 699-702 (May 2006) ISSN: 1592-8721 [Electronic] Italy
PMID	16627257 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Antibodies, Anticardiolipin Antibodies, Antiphospholipid Autoantibodies Autoantigens Glycoproteins Immunoglobulin G Phosphatidylserines beta 2-Glycoprotein I Adenosine Diphosphate Prothrombin
Topics	Abortion, Habitual (etiology, immunology) Adenosine Diphosphate (pharmacology) Adolescent Adult Aged Antibodies, Anticardiolipin (blood) Antibodies, Antiphospholipid (blood) Arterial Occlusive Diseases (blood, epidemiology, immunology) Autoantibodies (blood) Autoantigens (immunology) Child Enzyme-Linked Immunosorbent Assay Female Glycoproteins (immunology) Humans Immunoglobulin G (blood, immunology) Lupus Erythematosus, Systemic (blood, complications, immunology) Male Middle Aged Phosphatidylserines (immunology) Platelet Activation (drug effects) Pregnancy Prothrombin (immunology) Risk Factors Thrombophilia (blood, etiology, immunology) Venous Thrombosis (blood, epidemiology, immunology) beta 2-Glycoprotein I

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