Abstract | BACKGROUND: PATIENTS AND METHODS: In a retrospective study, 323 patients with melanoma ( tumor thickness > or = 0.75 mm) who underwent sentinel lymph node biopsy after both radionuclide and blue dye injection were evaluated. The labeling of lymph nodes showing micrometastasis by histopathological examination was determined. RESULTS: 63 patients showed sentinel lymph nodes with micrometastasis. All of these nodes (100 %) were labeled with radionuclide tracer, but only 90 % with blue dye. In 5 patients, only radionuclide labeling identified the histopathologically-positive lymph node. In 36 patients, several sentinel lymph nodes were identified, with the histopathologically-positive nodes usually showing a higher radioactive signal intensity than the negative ones. CONCLUSION: Since in some patients histopathologically-positive lymph nodes are only labeled by radionuclide tracer, radionuclide labeling is indispensable for locating sentinel lymph nodes. In contrast, labeling with blue dye represents a supplementary method, which can simplify the recognition of the sentinel lymph node during surgery.
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Authors | Wolfgang Pfützner, Christian Kunte, Mayo Weiss, Michael I Flaig, Birger Konz |
Journal | Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
(J Dtsch Dermatol Ges)
Vol. 4
Issue 3
Pg. 229-35
(Mar 2006)
ISSN: 1610-0379 [Print] Germany |
Vernacular Title | Intraoperative Markierung von Sentinel-Lymphknoten bei kombinierter Anwendung von Vitalfärbung und Radiotracer--Ergebnisse bei Sentinel-Lymphknoten-positiven Patienten. |
PMID | 16626319
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Radiopharmaceuticals
- Rosaniline Dyes
- sulfan blue
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Topics |
- Female
- Humans
- Intraoperative Care
(methods)
- Lymph Nodes
(diagnostic imaging, pathology)
- Lymphatic Metastasis
- Male
- Melanoma
(diagnosis, secondary, surgery)
- Radionuclide Imaging
- Radiopharmaceuticals
- Reproducibility of Results
- Retrospective Studies
- Rosaniline Dyes
- Sensitivity and Specificity
- Sentinel Lymph Node Biopsy
(methods)
- Skin Neoplasms
(diagnostic imaging, pathology, surgery)
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