Hemodynamic deterioration due to left ventricular outflow tract (
LVOT) obstruction can occur during
catecholamine infusion in patients with
acute coronary syndrome (ACS). The purpose of the present study was to compare the utility of
propranolol,
phenylephrine infusion, and rapid saline loading for reversal of
dobutamine-induced
LVOT obstruction in a canine model of ACS. ACS was induced via left anterior descending artery
ligation in 21 open-chest anesthetized dogs, and
LVOT obstruction, defined as an LVOT gradient > 30 mmHg, was induced by
dobutamine infusion (20 to 40 microg/kg/min). Subsequently, the effects of
propranolol infusion (0.7 to 1.0 microg/kg/min, n = 8),
phenylephrine infusion (10 to 200 microg/kg/min, n = 7), and saline loading (200 to 400 mL/hr, n = 6) were assessed by serial hemodynamic measurements. All interventions produced significant and comparable improvements in the LVOT pressure gradient (
propranolol: 60 +/- 16 to 15 +/- 12;
phenylephrine: 68 +/- 15 to 12 +/- 10; saline loading: 58 +/- 18 to 22 +/- 10 mmHg; P < 0.001 for baseline versus postintervention; P = NS for comparison between interventions).
Phenylephrine produced the greatest elevation in aortic pressure (
propranolol: +15 +/- 13;
phenylephrine: +51 +/- 36; saline loading: +15 +/- 15 mmHg; P < 0.05), while saline loading produced the greatest increase in cardiac output (
propranolol: +0.05 +/- 0.12;
phenylephrine: +0.28 +/- 0.37; saline loading: +0.73 +/- 0.48 L/min; P < 0.05).
Propranolol was the only intervention that produced a significant decrease in diastolic pulmonary artery pressure (16 +/- 5 to 11 +/- 3 mmHg, P < 0.05).
Propranolol,
phenylephrine infusion, and saline volume loading were similarly effective in reversing
dobutamine-induced
LVOT obstruction in this canine model of ACS. However, each intervention produced different hemodynamic effects with potentially different clinical indications.