Anti-inflammatory and antinociceptive potential of Maclura pomifera (Rafin.) Schneider fruit extracts and its major isoflavonoids, scandenone and auriculasin.

Abstract

The aqueous, ethanolic and chloroform extracts and two prenylated isoflavones: scandenone (I) and auriculasin (II), isolated from the fruits of Maclura pomifera (Rafin.) Schneider, were investigated for their in vivo anti-inflammatory and antinociceptive activity. For the anti-inflammatory activity, both carrageenan-induced hind paw edema and 12-O-tetradecanoyl-13-acetate (TPA)-induced mouse ear edema models and for the antinociceptive activity, p-benzoquinone-induced abdominal constriction test were used. Scandenone, the chloroform and the ethanolic extracts were shown to possess antinociceptive activity and anti-inflammatory activity on carrageenan-induced hind paw edema model at 100 mg/kg dose. The same compound and the extract were also found to be highly active in (TPA)-induced mouse ear edema model whereas auriculasin and the H(2)O extract showed to be inactive in all of the assays.

• Authors: Esra Kupeli, Ilkay Orhan, Gulnur Toker, Erdem Yesilada
• Journal: Journal of ethnopharmacology (J Ethnopharmacol) Vol. 107 Issue 2 Pg. 169-74 (Sep 19 2006) ISSN: 0378-8741 [Print] Ireland
• PMID: 16600547 (Publication Type: Journal Article)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Flavonoids
• Isoflavones
• Plant Extracts
• Solvents
• auriculasin
• scandenone

Topics

• Animals
• Anti-Inflammatory Agents, Non-Steroidal (pharmacology, therapeutic use, toxicity)
• Disease Models, Animal
• Edema (drug therapy)
• Flavonoids (pharmacology, therapeutic use, toxicity)
• Fruit (chemistry)
• Isoflavones (pharmacology, therapeutic use, toxicity)
• Maclura (chemistry)
• Male
• Mice
• Molecular Structure
• Pain (drug therapy)
• Plant Extracts (pharmacology, therapeutic use, toxicity)
• Solvents
• Stomach Ulcer (chemically induced)